Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.60 |
| ▸ | FPR2 | P25090 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | ECE1 | P42892 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11069816 | 0.90 | ACE (0.71) | ACEECE1LMNANAALAD2 | |
| SCHEMBL11064886 | 0.89 | ACE (0.62) | ACEMMP2ECE1LMNAMMP9 | |
| SCHEMBL11067560 | 0.87 | ACE (0.60) | ACEMEN1KMT2AECE1LMNA | |
| SCHEMBL11068248 | 0.84 | FPR2 (0.61) | ACEFPR2MEN1KMT2AMMP1 | |
| SCHEMBL17624790 | 0.80 | NAALAD2 (0.68) | ACELMNANAALAD2 | |
| SCHEMBL17261298 | 0.80 | NAALAD2 (0.68) | ACELMNANAALAD2 | |
| SCHEMBL11063947 | 0.80 | ACE (0.60) | ACEECE1LMNANAALAD2 | |
| SCHEMBL31006612 | 0.79 | ITGB1 (0.56) | ACEFPR2MMP2MMP1MMP3 | |
| SCHEMBL2806565 | 0.78 | FAAH (0.67) | ACENAALAD2 | |
| SCHEMBL2806570 | 0.78 | FAAH (0.67) | ACENAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435329-A | ANTIHYPERTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1984-03-06 | — | — | US | disclosed |