SCHEMBL11065262

SCHEMBL11065262

CCOC(=O)C(C)c1cccc(Oc2ccccc2)c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 2/20 0.70
MEN1 O00255 1/20 0.63
CYP2D6 P10635 1/20 0.63
KMT2A Q03164 1/20 0.63
ALOX5 P09917 1/20 0.53
GLI1 P08151 1/20 0.52
GLI2 P10070 1/20 0.52
NPC1 O15118 1/20 0.48
HPGD P15428 1/20 0.48
CRHBP P24387 1/20 0.48
RAB9A P51151 1/20 0.48
CRHR2 Q13324 1/20 0.48
FFAR1 O14842 1/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
PTGS2 P35354 1/20 0.47
HTR1D P28221 1/20 0.46
HTR1B P28222 1/20 0.46
MMP8 P22894 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11645560 0.87 PTGS1 (0.65) PTGS1MEN1CYP2D6KMT2AALOX5
SCHEMBL9719787 0.87 PTGS1 (0.59) PTGS1MEN1CYP2D6KMT2AALOX5
SCHEMBL28521689 0.86 PTGS1 (0.67) PTGS1MEN1CYP2D6KMT2AALOX5
SCHEMBL15271401 0.85 PTGS1 (0.57) PTGS1MEN1CYP2D6KMT2AALOX5
SCHEMBL28450158 0.85 PTGS1 (0.74) PTGS1MEN1CYP2D6KMT2AALOX5
SCHEMBL5110018 0.85 PTGS1 (0.74) PTGS1MEN1CYP2D6KMT2AALOX5
SCHEMBL8755064 0.85 PTGS1 (0.74) PTGS1MEN1CYP2D6KMT2AALOX5
SCHEMBL3918115 0.85 L3MBTL1 (0.55) PTGS1MEN1KMT2AALDH1A1
SCHEMBL28450157 0.85 PTGS1 (0.74) PTGS1MEN1CYP2D6KMT2AALOX5
SCHEMBL24027505 0.85 PTGS1 (0.65) PTGS1MEN1CYP2D6KMT2AALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0074008-B1 PROCESS FOR PRODUCING ALPHA-ARYLALKANOIC ACID ESTERS TAISHO PHARMACEUTICAL CO. LTD (JP) 1984-10-10 EP disclosed
US-4433160-A Process for producing α-arylalkanoic acid ester TAISHO PHARMACEUTICAL COMPANY, LTD. (JP) 1984-02-21 US disclosed
EP-0074008-A2 Process for producing alpha-arylalkanoic acid esters TAISHO PHARMACEUTICAL CO. LTD (JP) 1983-03-16 EP disclosed
US-4145557-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS ELI LILLY AND COMPANY (US) 1979-03-20 US disclosed
US-4062895-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC ELI LILLY AND COMPANY (US) 1977-12-13 US disclosed
US-4001322-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC ELI LILLY AND COMPANY (US) 1977-01-04 US disclosed
US-3972934-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC ELI LILLY AND COMPANY (US) 1976-08-03 US disclosed