Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15271401 | 0.87 | PTGS1 (0.57) | PTGS1MMP8MEN1KMT2ACYP2D6 | |
| SCHEMBL11065262 | 0.87 | PTGS1 (0.70) | PTGS1MMP8MEN1KMT2ACYP2D6 | |
| SCHEMBL1433326 | 0.84 | L3MBTL1 (0.56) | MMP8TDP1ALDH1A1 | |
| SCHEMBL11167719 | 0.82 | PTGS1 (0.52) | PTGS1MMP8MEN1KMT2ACYP2D6 | |
| SCHEMBL266419 | 0.82 | MMP8 (0.74) | MMP8MEN1KMT2ANPC1TDP1 | |
| SCHEMBL6475085 | 0.81 | MMP8 (0.49) | PTGS1MMP8HPGDAKR1C3PTGS2 | |
| SCHEMBL8796964 | 0.80 | PTGS1 (0.70) | PTGS1MEN1KMT2ACYP2D6ALOX5 | |
| SCHEMBL11645560 | 0.80 | PTGS1 (0.65) | PTGS1MEN1KMT2ACYP2D6ALOX5 | |
| SCHEMBL11139346 | 0.80 | PTGS1 (0.57) | PTGS1MEN1KMT2ACYP2D6ALOX5 | |
| SCHEMBL31069943 | 0.80 | MMP8 (0.72) | MMP8MEN1KMT2ANPC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5078906-A | Organic lithium-potassium complexes for metallization reactions, preparation of aspirin substitutes, fenoprofen | MINE SAFETY APPLIANCES COMPANY (US) | 1992-01-07 | — | — | US | disclosed |
| US-4910337-A | Process for the preparation of α-arylalkanoic acids | MINE SAFETY APPLIANCES COMPANY (US) | 1990-03-20 | — | — | US | disclosed |
| EP-0025262-B1 | ALPHA-THIO-ALPHA-ARYL-SUBSTITUTED ALKANONITRILES, PROCESS FOR THEIR PREPARATION, PROCESS FOR PREPARING ALPHA-ARYL-SUBSTITUTED ALKANONITRILES AND THE CORRESPONDING CARBOXYLIC ACIDS THEREFROM AND PROCESS FOR PREPARING INTERMEDIATES | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1983-10-05 | — | — | EP | disclosed |
| US-4340740-A | Alpha-thio-alpha-aryl-substituted alkanonitrile and process for preparing alpha-aryl-substituted alkanonitrile therefrom | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1982-07-20 | — | — | US | disclosed |
| US-4308208-A | α-Methylthio-α-(p-phthalimidophenyl)-propionic acid | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1981-12-29 | — | — | US | disclosed |
| US-4278802-A | METHYLTHIO-/P-/2-THIENYLCARBONYL/PHENYL/PROPIONIC ACID OR ESTER, PHARMACEUTICAL INTERMEDIATES | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1981-07-14 | — | — | US | disclosed |
| US-4242519-A | DRUG INTERMEDIATES | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1980-12-30 | — | — | US | disclosed |
| US-4237298-A | Aromatic acetic acid derivatives having sulfur atom at alpha-position and process for their preparation | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1980-12-02 | — | — | US | disclosed |
| US-4144248-A | Aromatic acetic acid derivatives having sulfur atom at alpha-position and process for their preparation | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1979-03-13 | — | — | US | disclosed |