Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | GLI1 | P08151 | 1/20 | 0.54 |
| ▸ | GLI2 | P10070 | 1/20 | 0.54 |
| ▸ | ACACB | O00763 | 1/20 | 0.50 |
| ▸ | ACACA | Q13085 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8755064 | 1.00 | PTGS1 (0.74) | PTGS1KMT2AMEN1CYP2D6PTGS2 | |
| SCHEMBL24476961 | 0.88 | PTGS1 (0.58) | PTGS1KMT2AMEN1CYP2D6PTGS2 | |
| SCHEMBL28450157 | 0.88 | PTGS1 (0.74) | PTGS1KMT2AMEN1CYP2D6PTGS2 | |
| SCHEMBL28450158 | 0.88 | PTGS1 (0.74) | PTGS1KMT2AMEN1CYP2D6PTGS2 | |
| SCHEMBL11320693 | 0.86 | PTGS1 (0.63) | PTGS1KMT2AMEN1CYP2D6PTGS2 | |
| SCHEMBL6922515 | 0.86 | PTGS1 (0.72) | PTGS1KMT2AMEN1CYP2D6PTGS2 | |
| SCHEMBL11759879 | 0.86 | PTGS1 (0.72) | PTGS1KMT2AMEN1CYP2D6PTGS2 | |
| SCHEMBL5352751 | 0.85 | PTGS1 (0.60) | PTGS1KMT2AMEN1PTGS2L3MBTL1 | |
| Fenoprofen SCHEMBL8754928 | 0.85 | PTGS1 (1.00) | PTGS1KMT2AMEN1CYP2D6PTGS2 | |
| (S)-Fenoprofen SCHEMBL4492279 | 0.85 | PTGS1 (1.00) | PTGS1KMT2AMEN1CYP2D6PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4357346-A1 | EXTERNAL ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Coval Biopharma (Shanghai) Co., Ltd. (CN) | 2024-04-24 | — | — | EP | disclosed |
| WO-2023001045-A9 | EXTERNAL ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海椿安生物医药科技有限公司 | 2023-10-26 | — | — | WO | disclosed |
| US-20230227425-A1 | REAGENTS AND PROCESS FOR DIRECT C-H FUNCTIONALIZATION | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2023-07-20 | — | — | US | disclosed |
| US-20230227425-A1 | REAGENTS AND PROCESS FOR DIRECT C-H FUNCTIONALIZATION | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2023-07-20 | — | — | US | disclosed |
| WO-2023001045-A1 | EXTERNAL ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海椿安生物医药科技有限公司 | 2023-01-26 | — | — | WO | disclosed |
| US-20220169581-A1 | DIRECT AROMATIC CARBON-OXYGEN AND CARBON-HYDROGEN BOND FUNCTIONALIZATION VIA ORGANIC PHOTOREDOX CATALYST | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2022-06-02 | — | — | US | disclosed |
| US-20220002263-A1 | REAGENTS AND PROCESS FOR DIRECT C-H FUNCTIONALIZATION | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2022-01-06 | — | — | US | disclosed |
| CN-105669531-B | The prodrug of non-steroidal anti-inflammatory drugs with fast skin and membranes penetration speed and its new medical usage | 于崇曦 | 2019-05-07 | — | — | CN | disclosed |
| CN-105820107-A | Prodrug of non-steroidal anti-inflammatory drug with rapid skin and biomembrane penetration velocity and novel medical application thereof | 于崇曦 | 2016-08-03 | — | — | CN | disclosed |
| CN-105669531-A | Prodrug of non-steroidal anti-inflammatory drug having high skin and biological membrane penetration speed and novel medical application thereof | 于崇曦 | 2016-06-15 | — | — | CN | disclosed |
| US-4242519-A | DRUG INTERMEDIATES | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1980-12-30 | — | — | US | disclosed |
| US-4237298-A | Aromatic acetic acid derivatives having sulfur atom at alpha-position and process for their preparation | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1980-12-02 | — | — | US | disclosed |
| US-4226790-A | ALKANOATE SALTS, WITH PEROXY CARBOXYLIC ACID, MANGANESE SALT | THE UPJOHN COMPANY (US) | 1980-10-07 | — | — | US | disclosed |
| US-4145557-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS | ELI LILLY AND COMPANY (US) | 1979-03-20 | — | — | US | disclosed |
| US-4144248-A | Aromatic acetic acid derivatives having sulfur atom at alpha-position and process for their preparation | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1979-03-13 | — | — | US | disclosed |
| US-4142054-A | TRIVALENT THALLIUM SALT | THE UPJOHN COMPANY (US) | 1979-02-27 | — | — | US | disclosed |
| US-4135051-A | ENOL ETHER OF AN ARYL ALKYL KETONE WITH A THALLIJM SALT, REGENERATION OF THALLIUM SALT BY ADDING PERACID AND REACTIVE METAL COMPOUND | THE UPJOHN COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4062895-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | ELI LILLY AND COMPANY (US) | 1977-12-13 | — | — | US | disclosed |
| US-4001322-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | ELI LILLY AND COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-3972934-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | ELI LILLY AND COMPANY (US) | 1976-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227425-A1 | REAGENTS AND PROCESS FOR DIRECT C-H FUNCTIONALIZATION | CFH, DOHH, CTSH | PTGS1 3936/4885KMT2A 867/4885MEN1 2782/4885 |
| US-20220002263-A1 | REAGENTS AND PROCESS FOR DIRECT C-H FUNCTIONALIZATION | CFH, DOHH, CTSH | PTGS1 3936/4885KMT2A 867/4885MEN1 2782/4885 |
| US-20220169581-A1 | DIRECT AROMATIC CARBON-OXYGEN AND CARBON-HYDROGEN BOND FUNCTIONALIZATION VIA ORGANIC PHOTOREDOX CATALYST | PPOX, CYCS, SCO2 | PTGS1 4156/4885KMT2A 2913/4885MEN1 4494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.