Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 3/20 | 0.37 |
| ▸ | PLAU | P00749 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074215 | 0.90 | HPSE (0.39) | PDE5AHPSEMAPTKMT2A | |
| SCHEMBL11071981 | 0.84 | PDE5A (0.41) | PDE5AHPSEMAPTRECQLBLM | |
| SCHEMBL11065296 | 0.83 | PDE5A (0.38) | PDE5AHPSEMAPTTP53KMT2A | |
| SCHEMBL11061395 | 0.82 | PDE5A (0.39) | PDE5AHPSEMAPTHSD17B10KMT2A | |
| SCHEMBL11018065 | 0.78 | PDE5A (0.37) | PDE5AMAPTRECQLALDH1A1PLG | |
| SCHEMBL9636112 | 0.76 | PDE5A (0.41) | PDE5AALDH1A1PLGPLAUF10 | |
| SCHEMBL10733507 | 0.76 | PDE5A (0.38) | PDE5AMAPTRECQLBLMCACNA1B | |
| SCHEMBL11066087 | 0.76 | KMT2A (0.43) | PDE5AHPSEMAPTALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL11350743 | 0.73 | GUSB (0.35) | PDE5APLGPLAUF10F2 | |
| SCHEMBL10762206 | 0.73 | PDE5A (0.41) | PDE5AHPSEMAPTALDH1A1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |