Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 10/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 9/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.67 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21466987 | 0.87 | CHRM2 (0.85) | CHRM2CHRM4CHRM1CHRM3MAPT | |
| SCHEMBL10201439 | 0.84 | CYP1A2 (0.48) | CHRM2CHRM4CHRM1CHRM3ALDH1A1 | |
| SCHEMBL28638610 | 0.80 | CHRM2 (1.00) | CHRM2CHRM4CHRM1CHRM3MAPT | |
| SCHEMBL29930240 | 0.80 | CHRM2 (1.00) | CHRM2CHRM4CHRM1CHRM3MAPT | |
| SCHEMBL28638613 | 0.79 | CHRM2 (1.00) | CHRM2CHRM4CHRM1CHRM3MAPT | |
| SCHEMBL29930511 | 0.79 | CHRM2 (1.00) | CHRM2CHRM4CHRM1CHRM3MAPT | |
| SCHEMBL1520072 | 0.78 | MEN1 (0.70) | CHRM2CHRM4CHRM1CHRM3MAPT | |
| SCHEMBL28003949 | 0.74 | MEN1 (0.79) | CHRM2CHRM4CHRM1CHRM3MAPT | |
| SCHEMBL9250671 | 0.74 | ALDH1A1 (0.68) | CHRM2CHRM4CHRM1CHRM3MAPT | |
| SCHEMBL19149082 | 0.74 | MEN1 (0.63) | CHRM2CHRM4CHRM1CHRM3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153655-B2 | Compositions useful as inhibitors of voltage-gated sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-20100087479-A1 | Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087479-A1 | Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels | SCNN1G, KCNN3, KCNN2 | CHRM2 1093/4885CHRM4 1075/4885CHRM1 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.