Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | FFAR2 | O15552 | 12/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10938811 | 1.00 | ACE (0.63) | ACELMNAFFAR2HTTALDH1A1 | |
| SCHEMBL10941478 | 0.90 | ACE (0.51) | ACELMNAFFAR2HTTALDH1A1 | |
| SCHEMBL10968292 | 0.88 | ACE (0.64) | ACELMNAFFAR2HTTALDH1A1 | |
| SCHEMBL11061433 | 0.87 | HSD17B10 (0.49) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL11096470 | 0.85 | ACE (0.61) | ACELMNAFFAR2HTTALDH1A1 | |
| SCHEMBL10939315 | 0.85 | ACE (0.49) | ACELMNAFFAR2HPGDHSD17B10 | |
| SCHEMBL11110323 | 0.85 | FFAR2 (0.47) | ACELMNAFFAR2HTT | |
| SCHEMBL10939281 | 0.84 | ACE (0.49) | ACELMNAFFAR2HTTALDH1A1 | |
| SCHEMBL683556 | 0.84 | ACE (0.67) | ACELMNA | |
| SCHEMBL11065988 | 0.84 | ACE (0.67) | ACELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4430344-A | Antihypertensive 4-thiazolidinecarboxylic acids | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-02-07 | — | — | US | claimed |
| US-4457935-A | ANGIOTENSIN-CONVERTING ENZYME INHIBITOR | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-07-03 | — | — | US | disclosed |
| US-4430344-A | Antihypertensive 4-thiazolidinecarboxylic acids | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-02-07 | — | — | US | disclosed |
| US-4423054-A | Antihypertensive 4-thiazolidinecarboxylic acids (substituted alkyl derivatives) | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-12-27 | — | — | US | disclosed |
| US-4386096-A | ANGIOTENSIN-CONVERTING ENZYME INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-05-31 | — | — | US | disclosed |
| US-4356183-A | ENZYME INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-10-26 | — | — | US | disclosed |