Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | FFAR2 | O15552 | 7/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10938811 | 0.87 | ACE (0.63) | HSD17B10FFAR2ACEPOLBALDH1A1 | |
| SCHEMBL11066109 | 0.87 | ACE (0.63) | HSD17B10FFAR2ACEPOLBALDH1A1 | |
| SCHEMBL11067693 | 0.86 | ACE (0.41) | HSD17B10FFAR2ACEPOLBALDH1A1 | |
| SCHEMBL11100929 | 0.82 | HSD17B10 (0.52) | HSD17B10FFAR2ACEPOLBGAA | |
| SCHEMBL11110245 | 0.81 | HSD17B10 (0.48) | HSD17B10FFAR2ACEPOLBGAA | |
| SCHEMBL11110323 | 0.80 | FFAR2 (0.47) | FFAR2ACELMNA | |
| SCHEMBL11192007 | 0.80 | ACE (0.38) | FFAR2ACE | |
| SCHEMBL11061441 | 0.79 | HSD17B10 (0.49) | HSD17B10FFAR2ACEPOLBGAA | |
| SCHEMBL10941478 | 0.77 | ACE (0.51) | FFAR2ACEPOLBALDH1A1MEN1 | |
| SCHEMBL10995336 | 0.77 | FFAR2 (0.43) | FFAR2ACELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4430344-A | Antihypertensive 4-thiazolidinecarboxylic acids | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-02-07 | — | — | US | disclosed |
| US-4423054-A | Antihypertensive 4-thiazolidinecarboxylic acids (substituted alkyl derivatives) | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-12-27 | — | — | US | disclosed |
| US-4386096-A | ANGIOTENSIN-CONVERTING ENZYME INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-05-31 | — | — | US | disclosed |
| US-4356183-A | ENZYME INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-10-26 | — | — | US | disclosed |