Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of 1-Hydroxy-3-Methoxybenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | CES2 | O00748 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Hydroxy-3-Methoxybenzene SCHEMBL11069761 | 1.00 | ESR1 (0.67) | ESR1ESR2RAB9ANPC1CA1 | |
| Benzophenone SCHEMBL27951827 | 0.90 | ESR1 (0.67) | ESR1ESR2RAB9ANPC1CES2 | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL9623569 | 0.85 | ESR1 (0.59) | ESR1ESR2RAB9ANPC1CA1 | |
| P-Anisic Acid SCHEMBL11774720 | 0.85 | CA1 (0.67) | ESR1ESR2RAB9ANPC1CA1 | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL28214358 | 0.83 | ESR1 (0.67) | ESR1ESR2RAB9ANPC1CES2 | |
| SCHEMBL6827745 | 0.83 | CES2 (0.74) | RAB9ANPC1CA1CA2CES2 | |
| SCHEMBL63427 | 0.83 | CES2 (0.74) | RAB9ANPC1CA1CA2CES2 | |
| SCHEMBL29351426 | 0.83 | CES2 (0.74) | RAB9ANPC1CA1CA2CES2 | |
| Benzoic Acid SCHEMBL20455946 | 0.83 | CA1 (0.75) | RAB9ANPC1CA1CA2CES2 | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL28256 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478876-A | BLEND OF ACRYLATE MONOMER, COLLOIDAL SILICA, ACRYLOXY FUNCTIONAL SILANE, AND PHOTOINITIATORS | GENERAL ELECTRIC COMPANY (US) | 1984-10-23 | — | — | US | claimed |