Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 2/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11066526 | 1.00 | RAB9A (0.41) | RAB9ASMN1; SMN2NPC1L3MBTL1NFKB1 | |
| SCHEMBL11075813 | 0.96 | SPHK1 (0.43) | RAB9ASMN1; SMN2NPC1RARBSPHK1 | |
| SCHEMBL11075810 | 0.96 | SPHK1 (0.43) | RAB9ASMN1; SMN2NPC1RARBSPHK1 | |
| SCHEMBL11069662 | 0.94 | SPHK1 (0.40) | RAB9ASMN1; SMN2NPC1L3MBTL1NFKB1 | |
| SCHEMBL11069649 | 0.94 | SPHK1 (0.40) | RAB9ASMN1; SMN2NPC1L3MBTL1NFKB1 | |
| SCHEMBL11072458 | 0.92 | MAOA (0.37) | RAB9ASMN1; SMN2NPC1L3MBTL1MAPK1 | |
| SCHEMBL11072460 | 0.92 | MAOA (0.37) | RAB9ASMN1; SMN2NPC1L3MBTL1MAPK1 | |
| SCHEMBL11070004 | 0.91 | SPHK1 (0.43) | RAB9ASMN1; SMN2NPC1RARBSPHK1 | |
| SCHEMBL11070000 | 0.91 | SPHK1 (0.43) | RAB9ASMN1; SMN2NPC1RARBSPHK1 | |
| SCHEMBL11070006 | 0.90 | GAA (0.39) | RAB9ASMN1; SMN2NPC1MAPK1SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4462923-A | Disubstituted pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1984-07-31 | — | — | US | claimed |
| US-4462923-A | Disubstituted pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1984-07-31 | — | — | US | disclosed |