Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559647 | 0.81 | SIGMAR1 (0.46) | SIGMAR1OPRD1KDM4ETDP1CHRM5 | |
| SCHEMBL11066538 | 0.81 | SIGMAR1 (0.63) | SIGMAR1OPRD1KDM4ETDP1CHRM5 | |
| SCHEMBL4899605 | 0.75 | OPRD1 (0.53) | OPRD1ALDH1A1OPRM1MEN1KMT2A | |
| SCHEMBL17275983 | 0.72 | OPRD1 (0.41) | SIGMAR1OPRD1CHRM5CHRM3OPRM1 | |
| SCHEMBL11070233 | 0.72 | SIGMAR1 (0.60) | SIGMAR1TDP1CHRM5CHRM3GNAI3 | |
| SCHEMBL11066224 | 0.71 | SIGMAR1 (0.59) | SIGMAR1GNAI3GNAO1GNAI1USP2 | |
| SCHEMBL11060304 | 0.70 | SIGMAR1 (0.58) | SIGMAR1GNAI3GNAO1GNAI1 | |
| SCHEMBL10818831 | 0.69 | KMT2A (0.55) | TDP1MEN1KMT2A | |
| SCHEMBL29004649 | 0.68 | SIGMAR1 (0.48) | SIGMAR1TDP1CHRM3SLC6A2SLC6A4 | |
| SCHEMBL8508634 | 0.68 | SIGMAR1 (0.59) | SIGMAR1OPRD1CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493512-A2 | TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS | General Electric Company (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051422-A2 | TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS | GENERAL ELECTRIC COMPANY (US) | 2011-05-05 | — | — | WO | disclosed |