Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11073141 | 0.92 | AKR1B1 (0.42) | ALDH1A1KDM4EMAPTSMN1; SMN2HPGD | |
| SCHEMBL11068485 | 0.88 | L3MBTL1 (0.42) | ALDH1A1KDM4EMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL11071003 | 0.86 | MAPK14 (0.42) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL11066911 | 0.86 | KDM1A (0.41) | ALDH1A1KDM4EMAPTSMN1; SMN2HPGD | |
| SCHEMBL11186665 | 0.83 | KDM1A (0.36) | ALDH1A1KDM4EMAPTSMN1; SMN2HPGD | |
| SCHEMBL11191093 | 0.82 | KDM1A (0.38) | ALDH1A1KDM4EMAPTSMN1; SMN2HPGD | |
| SCHEMBL11063915 | 0.81 | MEN1 (0.42) | ALDH1A1KDM4EMAPTSMN1; SMN2HPGD | |
| SCHEMBL11158853 | 0.80 | AKR1B1 (0.50) | ALDH1A1KDM4EMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL11068179 | 0.79 | L3MBTL1 (0.45) | ALDH1A1MAPTSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL11065609 | 0.78 | HRH1 (0.39) | ALDH1A1KDM4EMAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4444981-A | ANTIINFLAMMATORY, ANALGESICS | BEECHAM GROUP LIMITED (GB) | 1984-04-24 | — | — | US | disclosed |
| EP-0024807-B1 | BENZOCYCLOHEPTAPYRROLEALKANOIC ACIDS AND THEIR DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1983-11-02 | — | — | EP | disclosed |
| US-4359423-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | BEECHAM GROUP LIMITED (GB) | 1982-11-16 | — | — | US | disclosed |