Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.39 |
| ▸ | SLC6A15 | Q9H2J7 | 5/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11066911 | 0.92 | KDM1A (0.41) | HRH1SLC6A15SRD5A1SRD5A2LMNA | |
| SCHEMBL11068179 | 0.90 | L3MBTL1 (0.45) | SRD5A1LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL11066774 | 0.90 | SRD5A1 (0.43) | HRH1SLC6A15SRD5A1SRD5A2AKR1B1 | |
| SCHEMBL11065512 | 0.88 | MAPK14 (0.40) | SRD5A1LMNAMAPTTSHRCYP2C19 | |
| SCHEMBL11060030 | 0.87 | LMNA (0.36) | HRH1SLC6A15LMNAMAPTCYP3A4 | |
| SCHEMBL11073141 | 0.86 | AKR1B1 (0.42) | LMNAMAPTCYP3A4ALOX15SMN1; SMN2 | |
| SCHEMBL11068485 | 0.82 | L3MBTL1 (0.42) | SRD5A1LMNAMAPTCYP3A4SMN1; SMN2 | |
| SCHEMBL11071003 | 0.80 | MAPK14 (0.42) | SRD5A1TSHRCYP2C19SMN1; SMN2MEN1 | |
| SCHEMBL11070255 | 0.80 | AKR1B1 (0.40) | SRD5A1LMNAMAPTCYP2C9MEN1 | |
| SCHEMBL11182632 | 0.80 | SMN1; SMN2 (0.35) | LMNAMAPTALOX15SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4444981-A | ANTIINFLAMMATORY, ANALGESICS | BEECHAM GROUP LIMITED (GB) | 1984-04-24 | — | — | US | disclosed |
| EP-0024807-B1 | BENZOCYCLOHEPTAPYRROLEALKANOIC ACIDS AND THEIR DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1983-11-02 | — | — | EP | disclosed |