Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11066786 | 0.92 | ALDH1A1 (0.45) | AKR1B1ALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL11158853 | 0.89 | AKR1B1 (0.50) | AKR1B1ALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL11068179 | 0.88 | L3MBTL1 (0.45) | AKR1B1ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL11065512 | 0.86 | MAPK14 (0.40) | AKR1B1ALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL11065609 | 0.86 | HRH1 (0.39) | AKR1B1ALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL11182632 | 0.83 | SMN1; SMN2 (0.35) | ALDH1A1L3MBTL1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL11187765 | 0.82 | L3MBTL1 (0.35) | ALDH1A1L3MBTL1SMN1; SMN2MAPTGAA | |
| SCHEMBL11073350 | 0.81 | AKR1B1 (0.45) | AKR1B1ALDH1A1L3MBTL1KDM4EMAPT | |
| SCHEMBL11059241 | 0.81 | SMN1; SMN2 (0.39) | AKR1B1ALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL11068485 | 0.79 | L3MBTL1 (0.42) | ALDH1A1L3MBTL1KDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4444981-A | ANTIINFLAMMATORY, ANALGESICS | BEECHAM GROUP LIMITED (GB) | 1984-04-24 | — | — | US | disclosed |
| EP-0024807-B1 | BENZOCYCLOHEPTAPYRROLEALKANOIC ACIDS AND THEIR DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1983-11-02 | — | — | EP | disclosed |
| EP-0024807-A1 | Benzocycloheptapyrrolealkanoic acids and their derivatives, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1981-03-11 | — | — | EP | disclosed |