Malonic Acid Diethyl Ester

Malonic Acid Diethyl Ester

SCHEMBL11067701

CCOC(=O)CC(=O)OCC.CN(C)Cc1ccccc1

nearest known ligand 0.57

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.57
TSHR P16473 1/20 0.57
NPC1 O15118 3/20 0.54
RAB9A P51151 3/20 0.54
PPID Q08752 1/20 0.51
LMNA P02545 1/20 0.51
POLB P06746 1/20 0.51
HSD17B10 Q99714 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
MGAM O43451 1/20 0.50
GAA P10253 1/20 0.50
SI P14410 1/20 0.50
MGAM2 Q2M2H8 1/20 0.50
MMP8 P22894 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
CA12 O43570 1/20 0.46
CA9 Q16790 1/20 0.46
TAAR1 Q96RJ0 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11190772 0.85 RAB9A (0.72) ALDH1A1NPC1RAB9APPIDLMNA
Ethyl Acetate SCHEMBL27878629 0.85 ALDH1A1 (0.59) ALDH1A1TSHRNPC1RAB9ALMNA
SCHEMBL10597046 0.81 RAB9A (0.49) ALDH1A1TSHRNPC1RAB9APPID
Hydrochloric Acid SCHEMBL2379884 0.81 ALDH1A1 (0.50) ALDH1A1TSHRNPC1RAB9ALMNA
SCHEMBL1557559 0.81 ALDH1A1 (0.61) ALDH1A1NPC1RAB9APPIDLMNA
SCHEMBL3851346 0.81 ALDH1A1 (0.49) ALDH1A1NPC1RAB9APPIDLMNA
SCHEMBL9636764 0.80 TSHR (0.68) ALDH1A1TSHRNPC1RAB9ALMNA
SCHEMBL8337648 0.80 ALDH1A1 (0.57) ALDH1A1TSHRNPC1RAB9APPID
Bicarbonate SCHEMBL4671806 0.80 ALDH1A1 (0.81) ALDH1A1TSHRNPC1RAB9ALMNA
Bicarbonate SCHEMBL14811027 0.80 ALDH1A1 (0.81) ALDH1A1TSHRNPC1RAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0025846-B1 IMPROVED PROCESS FOR THE PREPARATION OF VINYLCYCLOPROPANE DERIVATIVES NATIONAL DISTILLERS AND CHEMICAL CORPORATION (US) 1984-03-07 EP disclosed
EP-0025846-A1 Improved process for the preparation of vinylcyclopropane derivatives NATIONAL DISTILLERS AND CHEMICAL CORPORATION (US) 1981-04-01 EP disclosed
US-4252739-A ALKYLATING AGENT SUCH AS 1,4-DIHALO-2-BUTENE, AN ACTIVE METHYLENE COMPOUND, A CATALYTIC ONIUM COMPOUND, AN ALKALI METAL COMPOUND AND WATER; ONE STEP EMERY INDUSTRIES, INC. (US) 1981-02-24 US disclosed