Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11070733 | 0.85 | ALDH1A1 (0.39) | ALDH1A1LMNARECQLCYP1A2CYP2D6 | |
| SCHEMBL11060121 | 0.81 | RAD52 (0.39) | ALDH1A1RECQLCYP1A2SMN1; SMN2KDM4E | |
| SCHEMBL11016235 | 0.80 | ALDH1A1 (0.38) | ALDH1A1LMNARECQLCYP1A2CYP2D6 | |
| SCHEMBL11064822 | 0.79 | MAPT (0.41) | ALDH1A1RECQLSMN1; SMN2KDM4EGAA | |
| SCHEMBL11071024 | 0.79 | FAAH (0.36) | LMNACYP2C19CYP3A4KDM4EHPGD | |
| SCHEMBL9378832 | 0.74 | ALDH1A1 (0.36) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| Bemitradine SCHEMBL121173 | 0.73 | KDM4E (0.36) | ALDH1A1CYP1A2SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL9381563 | 0.72 | ADORA2A (0.35) | ALDH1A1LMNASMN1; SMN2KDM4ETNK2 | |
| SCHEMBL11070935 | 0.67 | ADORA2A (0.35) | ALDH1A1KDM4EMEN1KMT2AATM | |
| SCHEMBL11151560 | 0.67 | KDM5A (0.40) | ALDH1A1LMNASMN1; SMN2KDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129247-A1 | 8-Substituted 7-phenyl-1,2,4-triazolo [2,3-c] pyrimidines-5-amines and amides | G.D. Searle & Co. (US) | 1984-12-27 | — | — | EP | claimed |
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | claimed |
| EP-0129247-A1 | 8-Substituted 7-phenyl-1,2,4-triazolo [2,3-c] pyrimidines-5-amines and amides | G.D. Searle & Co. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | disclosed |