Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11073593 | 0.87 | ALDH1A1 (0.42) | ALDH1A1HPGDTNK2ADORA2AADORA2B | |
| SCHEMBL9381563 | 0.86 | ADORA2A (0.35) | ALDH1A1TNK2ADORA2AADORA2BSRC | |
| SCHEMBL10706002 | 0.84 | ALDH1A1 (0.36) | ALDH1A1HPGDHSD17B10EGLN1KDM4E | |
| SCHEMBL11070935 | 0.81 | ADORA2A (0.35) | ALDH1A1TNK2ADORA2AADORA2BMEN1 | |
| Bemitradine SCHEMBL121173 | 0.81 | KDM4E (0.36) | ALDH1A1HPGDHSD17B10ADORA2AADORA2B | |
| SCHEMBL11151560 | 0.81 | KDM5A (0.40) | ALDH1A1TNK2ADORA2AADORA2BSRC | |
| SCHEMBL11060121 | 0.81 | RAD52 (0.39) | ALDH1A1HPGDHSD17B10ADORA2AMEN1 | |
| SCHEMBL11062890 | 0.81 | EGLN1 (0.36) | ALDH1A1HPGDHSD17B10EGLN1TNK2 | |
| SCHEMBL11064822 | 0.79 | MAPT (0.41) | ALDH1A1HPGDHSD17B10TNK2ADORA2A | |
| SCHEMBL10430692 | 0.79 | XDH (0.42) | ALDH1A1HPGDADORA2AADORA2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129247-A1 | 8-Substituted 7-phenyl-1,2,4-triazolo [2,3-c] pyrimidines-5-amines and amides | G.D. Searle & Co. (US) | 1984-12-27 | — | — | EP | claimed |
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | claimed |
| EP-0374914-B1 | Diol metabolites of 7-phenyl-1,2,4-triazolo[1,5-c]-pyrimidines-5-amines | SEARLE & CO (US) | 1994-04-20 | — | — | EP | disclosed |
| EP-0374914-A1 | Diol metabolites of 7-phenyl-1,2,4-triazolo[1,5-c]-pyrimidines-5-amines | G.D. Searle & Co. (US) | 1990-06-27 | — | — | EP | disclosed |
| US-4866063-A | Diol metabolites of 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines | G. D. SEARLE & CO. (US) | 1989-09-12 | — | — | US | disclosed |
| EP-0129247-A1 | 8-Substituted 7-phenyl-1,2,4-triazolo [2,3-c] pyrimidines-5-amines and amides | G.D. Searle & Co. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | disclosed |