Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068442 | 0.84 | PKM (0.36) | NPC1CHRM5CHKAMAPTKDM4E | |
| SCHEMBL28952695 | 0.74 | — | — | |
| SCHEMBL3409151 | 0.66 | CHRM5 (0.68) | NPC1CHRM5CHKAMAPTKDM4E | |
| SCHEMBL5998646 | 0.65 | KDM4E (0.52) | NPC1CHRM5CHKAMAPTKDM4E | |
| SCHEMBL11068752 | 0.64 | PGK1 (0.40) | KDM4ESMN1; SMN2 | |
| SCHEMBL11119029 | 0.62 | CHRM5 (0.41) | NPC1CHRM5CHKAMAPTKDM4E | |
| Methoxymethane SCHEMBL8084405 | 0.61 | CHRM5 (0.84) | NPC1CHRM5CHKAMAPTKDM4E | |
| SCHEMBL10874328 | 0.60 | CHRM5 (0.94) | NPC1CHRM5CHKAMAPTKDM4E | |
| SCHEMBL2223507 | 0.59 | CHKA (0.56) | CHRM5CHKAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL1583518 | 0.59 | CHRM5 (0.56) | NPC1CHRM5CHKAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471122-A | Thiadiazole histamine H2 -antagonists | BRISTOL-MYERS COMPANY (US) | 1984-09-11 | — | — | US | claimed |
| US-4471122-A | Thiadiazole histamine H2 -antagonists | BRISTOL-MYERS COMPANY (US) | 1984-09-11 | — | — | US | disclosed |