Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068445 | 0.86 | LMNA (0.42) | PGK1ADRA2CLMNASMN1; SMN2HTT | |
| SCHEMBL11071310 | 0.70 | ALDH1A1 (0.49) | GAAPOLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10959707 | 0.69 | — | — | |
| SCHEMBL5998644 | 0.65 | MAPT (0.65) | GAALMNAALDH1A1KDM4ERAB9A | |
| SCHEMBL10755304 | 0.65 | PRKACA (0.51) | PGK1ADRA2CGAAPOLBLMNA | |
| SCHEMBL11066638 | 0.64 | ALDH1A1 (0.44) | PGK1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL11068749 | 0.64 | NPC1 (0.39) | SMN1; SMN2KDM4E | |
| SCHEMBL19236777 | 0.62 | GAA (0.47) | PGK1ADRA2CGAAPOLBLMNA | |
| SCHEMBL19241691 | 0.61 | F2 (0.56) | ADRA2CGAAHTTALDH1A1KDM4E | |
| SCHEMBL19242049 | 0.61 | KDM4E (0.61) | ADRA2CGAAPOLBHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471122-A | Thiadiazole histamine H2 -antagonists | BRISTOL-MYERS COMPANY (US) | 1984-09-11 | — | — | US | claimed |
| US-4471122-A | Thiadiazole histamine H2 -antagonists | BRISTOL-MYERS COMPANY (US) | 1984-09-11 | — | — | US | disclosed |