Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 5/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11007766 | 0.99 | CYP11B1 (0.55) | CYP11B1CYP11B2PPARGTBXAS1MTNR1A | |
| SCHEMBL11068110 | 0.87 | CYP11B1 (0.52) | CYP11B1CYP11B2PPARGTBXAS1MTNR1A | |
| Hydrochloric Acid SCHEMBL11075166 | 0.86 | CYP11B1 (0.51) | CYP11B1CYP11B2PPARGTBXAS1MTNR1A | |
| SCHEMBL11070611 | 0.86 | TBXAS1 (0.63) | PPARGTBXAS1TLR9FFAR1 | |
| Hydrochloric Acid SCHEMBL11005148 | 0.85 | TBXAS1 (0.61) | PPARGTBXAS1TLR9FFAR1 | |
| SCHEMBL23704287 | 0.81 | CYP11B1 (0.64) | CYP11B1CYP11B2MTNR1AMTNR1BTLR9 | |
| SCHEMBL29994013 | 0.81 | CYP11B1 (0.64) | CYP11B1CYP11B2MTNR1AMTNR1BTLR9 | |
| SCHEMBL11091325 | 0.77 | PPARG (0.52) | PPARGTBXAS1MTNR1AMTNR1BFNTA | |
| SCHEMBL29994022 | 0.75 | CYP11B1 (0.47) | CYP11B1CYP11B2MTNR1AMTNR1BTLR9 | |
| SCHEMBL23704400 | 0.75 | CYP11B1 (0.47) | CYP11B1CYP11B2MTNR1AMTNR1BTLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478842-A | THROMBOXANE SYNTHETASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1984-10-23 | — | — | US | disclosed |
| US-4460777-A | THROMBOXANE SYNTHETASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1984-07-17 | — | — | US | disclosed |
| EP-0080154-A2 | N-substituted 2-pyridyl indoles, process for their preparation, pharmaceutical compositions containing them, and their therapeutical use | CIBA-GEIGY AG (CH) | 1983-06-01 | — | — | EP | disclosed |