Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28165484 | 0.81 | VCAM1 (0.54) | VCAM1SRD5A2ATMTDP1L3MBTL1 | |
| SCHEMBL6113949 | 0.80 | PARP1 (0.41) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL31268519 | 0.77 | VCAM1 (0.50) | VCAM1SRD5A2ATMTDP1L3MBTL1 | |
| SCHEMBL28559554 | 0.77 | TDP1 (0.34) | SRD5A2ATMTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL635606 | 0.75 | MIF (0.59) | SRD5A2ATMTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL11445577 | 0.75 | S100B (0.58) | ATMALDH1A1ALOX15MEN1RAB9A | |
| SCHEMBL333237 | 0.75 | SRD5A2 (0.78) | VCAM1SRD5A2ATMTDP1L3MBTL1 | |
| SCHEMBL13123474 | 0.74 | ATM (0.57) | SRD5A2ATMTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL5145030 | 0.72 | AKR1C3 (0.50) | SRD5A2ATMTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL28736779 | 0.72 | CNR2 (0.59) | VCAM1SRD5A2ATMTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471117-A | ANTIDEPRESSANTS AND ANTI-PARKINSON AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-09-11 | — | — | US | disclosed |
| EP-0021807-B1 | 3,4-DIHYDRO-2H-PYRIMIDO (2,1-B) BENZOTHIAZOLES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-03-09 | — | — | EP | disclosed |
| EP-0021806-B1 | 2,3-DIHYDRO-IMIDAZO (2,1-B) BENZOTHIAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-12 | — | — | EP | disclosed |
| US-4364942-A | ANTIDEPRESSANTS, INHIBITORS OF MONOAMINE OXIDASE | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-21 | — | — | US | disclosed |
| US-4340738-A | ENZYME INHIBITORS, ANTIDEPRESSANTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-07-20 | — | — | US | disclosed |
| US-4262004-A | MONOAMINE OXIDASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-04-14 | — | — | US | disclosed |
| EP-0021806-A1 | 2,3-Dihydro-imidazo (2,1-b) benzothiazole derivatives and pharmaceutical compositions containing them | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-01-07 | — | — | EP | disclosed |
| EP-0021807-A1 | 3,4-Dihydro-2H-pyrimido (2,1-b) benzothiazoles and pharmaceutical compositions containing them | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-01-07 | — | — | EP | disclosed |