Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116656 | 0.82 | LMNA (0.46) | KMT2ANPC1ALDH1A1AKR1B1TP53 | |
| SCHEMBL21434703 | 0.80 | PTGER1 (0.57) | AKR1C3KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL21447041 | 0.80 | NPC1 (0.58) | AKR1C3KMT2ANPC1RAB9ASGMS2 | |
| SCHEMBL11357851 | 0.78 | MAOB (0.61) | SMN1; SMN2PTGER1LRRK2MCL1MAPT | |
| SCHEMBL3926335 | 0.77 | PTGER1 (0.67) | NPC1RAB9APTGER1MCL1 | |
| SCHEMBL16433347 | 0.76 | KLKB1 (0.46) | KMT2ARAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL31375951 | 0.76 | PTGER1 (0.58) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2562971 | 0.75 | ALDH1A1 (0.55) | KMT2AALDH1A1SMN1; SMN2TP53LMNA | |
| SCHEMBL1425720 | 0.75 | PTGER1 (0.56) | KMT2ANPC1RAB9APTGER1MCL1 | |
| SCHEMBL16348371 | 0.74 | CDK1 (0.56) | KMT2AMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153793-B2 | Sulfonamide derivative having PGD2 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2012-04-10 | — | — | US | disclosed |