Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 10/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270939 | 0.86 | MTOR (0.45) | MTORPIK3CAMAP4K4CCNCCDK8 | |
| SCHEMBL7272778 | 0.81 | DYRK1A (0.45) | MTORPIK3CAMAPK14DYRK1A | |
| SCHEMBL4619304 | 0.78 | GABRP (0.46) | MTORADORA2BGABRPGABRDGABRA1 | |
| SCHEMBL3702232 | 0.77 | DYRK1A (0.50) | MTORPIK3CAADORA2BMAP4K4CCNC | |
| SCHEMBL12773427 | 0.76 | MTOR (0.63) | MTORPIK3CAPIK3CB | |
| SCHEMBL7273135 | 0.76 | MTOR (0.42) | MTORPIK3CACCNCCDK8MAPK14 | |
| SCHEMBL16060934 | 0.76 | CSF1R (0.43) | MTORPIK3CAMAP4K4DYRK1A | |
| SCHEMBL11068665 | 0.74 | ABL1 (0.42) | — | |
| SCHEMBL11230737 | 0.74 | MTOR (0.40) | MTORPIK3CACCNCCDK8MAPK14 | |
| SCHEMBL11234214 | 0.74 | MTOR (0.41) | MTORPIK3CAMAP4K4CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448780-A | N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardiotonic use thereof | STERLING DRUG INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4420617-A | 5(Pyridinyl)pyridin-2-amines | STERLING DRUG INC. (US) | 1983-12-13 | — | — | US | disclosed |