Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273135 | 0.86 | MTOR (0.42) | MTORMAPK14AAK1PIK3CADYRK1A | |
| SCHEMBL11234214 | 0.80 | MTOR (0.41) | MTORMAPK14PIK3CADYRK1ANFATC1 | |
| SCHEMBL11229323 | 0.80 | CYP1A2 (0.46) | MTORAAK1 | |
| SCHEMBL11396219 | 0.79 | FTO (0.44) | MTORCCNCCDK8 | |
| SCHEMBL7270939 | 0.78 | MTOR (0.45) | MTORMAPK14PIK3CADYRK1ANFATC1 | |
| SCHEMBL11236490 | 0.78 | NCOA1 (0.39) | MTORCCNCCDK8HTT | |
| SCHEMBL11166411 | 0.78 | PIK3CB (0.47) | MTORAAK1CCNCCDK8 | |
| SCHEMBL11069334 | 0.74 | MTOR (0.55) | MTORMAPK14PIK3CADYRK1ACCNC | |
| SCHEMBL7272778 | 0.70 | DYRK1A (0.45) | MTORMAPK14PIK3CADYRK1ANFATC1 | |
| SCHEMBL11248447 | 0.70 | SMN1; SMN2 (0.40) | MAPK14MAPK1HTTGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351941-A | Pyridinyl-pyridines | STERLING DRUG INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |