SCHEMBL11069491

SCHEMBL11069491

C=C(C)C(=O)Nc1ccc(Cl)c(NC2=NN(c3c(Cl)cc(Cl)cc3Cl)C(=O)C2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 4/20 0.47
L3MBTL1 Q9Y468 4/20 0.47
RECQL P46063 4/20 0.47
GAA P10253 4/20 0.47
BLM P54132 2/20 0.47
MEN1 O00255 6/20 0.47
KMT2A Q03164 6/20 0.47
MAPT P10636 4/20 0.47
THRB P10828 1/20 0.47
HTT P42858 1/20 0.47
ALOX12 P18054 1/20 0.36
TDP1 Q9NUW8 4/20 0.35
GRK5 P34947 1/20 0.35
CDK8 P49336 1/20 0.35
BAZ1A Q9NRL2 1/20 0.33
P2RY1 P47900 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
ATAD2 Q6PL18 1/20 0.32
CECR2 Q9BXF3 1/20 0.32
IGF1R P08069 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9769433 0.90 MEN1 (0.50) POLBL3MBTL1RECQLGAABLM
SCHEMBL7499362 0.85 GAA (0.60) POLBL3MBTL1RECQLGAABLM
SCHEMBL14400382 0.83 MEN1 (0.43) POLBL3MBTL1RECQLGAABLM
SCHEMBL9195282 0.81 SMN1; SMN2 (0.45) POLBL3MBTL1RECQLGAAMEN1
SCHEMBL11047439 0.80 MEN1 (0.72) POLBL3MBTL1RECQLGAABLM
SCHEMBL12126416 0.80 KMT2A (0.45) POLBL3MBTL1RECQLGAABLM
SCHEMBL14045221 0.79 MEN1 (0.41) POLBL3MBTL1RECQLGAAMEN1
SCHEMBL10613765 0.77 KMT2A (0.42) POLBL3MBTL1RECQLGAAMEN1
SCHEMBL14429748 0.77 LMNA (0.43) POLBL3MBTL1RECQLGAAMEN1
SCHEMBL9344030 0.75 MEN1 (0.57) POLBL3MBTL1RECQLGAABLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4435503-A POLYMER COUPLER AND FORMALDEHYDE SCAVENGER FUJI PHOTO FILM CO., LTD. (JP) 1984-03-06 US disclosed