Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11283137 | 0.89 | PDE10A (0.52) | PDE10ADRD2HTR1ADRD1HTR2A | |
| SCHEMBL10601879 | 0.86 | DRD4 (0.54) | PDE10ADRD2HTR1ADRD1HTR2A | |
| Water SCHEMBL11063215 | 0.85 | DRD2 (0.54) | DRD2HTR1ADRD1HTR2AHTR2C | |
| SCHEMBL10601141 | 0.85 | PDE10A (0.55) | PDE10ADRD2HTR1AHTR2AKDM4E | |
| SCHEMBL11066123 | 0.85 | PDE10A (0.60) | PDE10ADRD2HTR1ADRD1HTR2A | |
| SCHEMBL11065995 | 0.83 | OPRM1 (0.56) | PDE10AHTR1ADRD1KDM4EDRD3 | |
| SCHEMBL11069350 | 0.83 | PDE10A (0.55) | PDE10AHTR1AKDM4ELMNAHTR3A | |
| SCHEMBL11062672 | 0.82 | MAPT (0.52) | PDE10AHTR1AKDM4ELMNADRD4 | |
| SCHEMBL11062449 | 0.81 | GRM2 (0.54) | PDE10ADRD2HTR1ADRD1HTR2A | |
| SCHEMBL11100918 | 0.80 | PDE10A (0.57) | PDE10AKDM4ELMNAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034249-B1 | NEW NAPHTHIMIDAZOLE AND NAPHTHOXAZOLE DERIVATIVES, THEIR PREPARATION, AND THEIR USE IN PHARMACEUTICALS | GRUPPO LEPETIT S.P.A. (IT) | 1984-10-24 | — | — | EP | disclosed |
| US-4461894-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1984-07-24 | — | — | US | disclosed |
| US-4360674-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1982-11-23 | — | — | US | disclosed |