Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 6/20 | 0.50 |
| ▸ | HTR7 | P34969 | 5/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11062412 | 0.89 | KCNH2 (0.50) | OPRM1KDM4EOPRD1HTR1AHTR7 | |
| SCHEMBL10601879 | 0.89 | DRD4 (0.54) | SIGMAR1HTR1AHTR7SLC6A4DRD1 | |
| SCHEMBL10601141 | 0.88 | PDE10A (0.55) | KDM4ESIGMAR1PARP1HTR1AHTR7 | |
| SCHEMBL11361973 | 0.87 | DRD2 (0.52) | HTR1AHTR7KCNH2DRD3HTR6 | |
| Water SCHEMBL11067600 | 0.86 | DRD2 (0.51) | HTR1AHTR7KCNH2DRD3HTR6 | |
| SCHEMBL11073089 | 0.86 | PDE10A (0.48) | KDM4EPARP1HTR1AHTR7DRD3 | |
| SCHEMBL10601043 | 0.85 | SIGMAR1 (0.56) | SIGMAR1HTR1AHTR7ADRA1ADRD3 | |
| SCHEMBL11069682 | 0.83 | PDE10A (0.52) | KDM4EHTR1AHTR7SLC6A4KCNH2 | |
| SCHEMBL11062672 | 0.83 | MAPT (0.52) | KDM4EHTR1AHTR7SLC6A4SLC6A2 | |
| SCHEMBL11282844 | 0.82 | PDE10A (0.53) | SIGMAR1PARP1HTR1AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034249-B1 | NEW NAPHTHIMIDAZOLE AND NAPHTHOXAZOLE DERIVATIVES, THEIR PREPARATION, AND THEIR USE IN PHARMACEUTICALS | GRUPPO LEPETIT S.P.A. (IT) | 1984-10-24 | — | — | EP | disclosed |
| US-4461894-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1984-07-24 | — | — | US | disclosed |
| US-4360674-A | Naphth[1,2-d]imidazoles | GRUPPO LEPETIT S.P.A. (IT) | 1982-11-23 | — | — | US | disclosed |
| EP-0034249-A2 | New naphthimidazole and naphthoxazole derivatives, their preparation, and their use in pharmaceuticals | GRUPPO LEPETIT S.P.A. (IT) | 1981-08-26 | — | — | EP | disclosed |