SCHEMBL11070068

SCHEMBL11070068

CC1N=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc2NC1=O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 3/20 0.48
GABRA5 P31644 3/20 0.48
GABRA3 P34903 3/20 0.48
GABRA2 P47869 3/20 0.48
GABRB2 P47870 3/20 0.48
GABRG2 P18507 2/20 0.47
GABRB3 P28472 2/20 0.47
CCKBR P32239 1/20 0.47
OPRK1 P41145 1/20 0.47
MC3R P41968 1/20 0.47
GHSR Q92847 1/20 0.47
GABRP O00591 1/20 0.47
GABRD O14764 1/20 0.47
GABRB1 P18505 1/20 0.47
ADRA1A P35348 1/20 0.47
GABRA4 P48169 1/20 0.47
GABRE P78334 1/20 0.47
GABRA6 Q16445 1/20 0.47
GABRG1 Q8N1C3 1/20 0.47
GABRG3 Q99928 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11075550 1.00 GABRA1 (0.48) GABRA1GABRA5GABRA3GABRA2GABRB2
SCHEMBL11081506 1.00 GABRA1 (0.48) GABRA1GABRA5GABRA3GABRA2GABRB2
SCHEMBL11716996 0.88 CHRM1 (0.50) GABRA1GABRA5GABRA3GABRA2GABRB2
SCHEMBL10971587 0.88 LMNA (0.54) GABRA1GABRA5GABRA3GABRA2GABRB2
SCHEMBL11462192 0.88 GABRA1 (0.47) GABRA1GABRA5GABRA3GABRA2GABRB2
SCHEMBL2109368 0.88 MEN1 (0.50) GABRA1GABRA5GABRA3GABRA2GABRB2
Meclonazepam SCHEMBL7269783 0.87 GABRA1 (0.63) GABRA1GABRA5GABRA3GABRA2GABRB2
Meclonazepam SCHEMBL2109365 0.87 GABRA1 (0.63) GABRA1GABRA5GABRA3GABRA2GABRB2
Meclonazepam SCHEMBL29365672 0.87 GABRA1 (0.63) GABRA1GABRA5GABRA3GABRA2GABRB2
SCHEMBL11073389 0.86 TRPV1 (0.52) CCKBRTRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0061765-B1 BETA-LACTAMS E.R. SQUIBB & SONS, INC. (US) 1985-08-28 EP claimed
EP-0008421-B1 BENZODIAZEPINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1984-02-08 EP disclosed
US-4327026-A Benzodiazepine derivatives HOFFMANN-LA ROCHE INC. (US) 1982-04-27 US disclosed
EP-0045452-A2 Benzodiazepine derivatives, intermediates and their preparation, and pharmaceutical compositions containing them F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1982-02-10 EP disclosed
US-4299767-A ANTIALDOSTERONES, HYPOTENSIVE AGENTS, TREATMENT OF HEART AND LEVER DISORDERS HOFFMANN-LA ROCHE INC. (US) 1981-11-10 US disclosed
US-4296031-A ALDOSTERONE ANTAGONIST HOFFMANN-LA ROCHE INC. (US) 1981-10-20 US disclosed
US-4294758-A ANTICHOLESTEROL AGENTS, CARDIOVASCULAR DISORDERS HOFFMANN-LA ROCHE INC. (US) 1981-10-13 US disclosed
US-4281188-A ANTIALDOSTERONES HOFFMANN-LA ROCHE INC. (US) 1981-07-28 US disclosed
US-4251443-A ALDOSTERONE ANTAGONISTS; PREVENTION OF HEART FAILURE, HEPATIC ASCITES, ALDOSTERONISM, HYPERTENSION HOFFMANN-LA ROCHE INC. (US) 1981-02-17 US disclosed
EP-0008421-A2 Benzodiazepine derivatives, process for their preparation and pharmaceutical compositions containing them F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1980-03-05 EP disclosed
US-4031078-A ANTHELMINTICS, MUSCLE RELAXANTS, ANTICONVULSANTS HOFFMANN-LA ROCHE INC. (US) 1977-06-21 US disclosed