Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.63 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.63 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.63 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.63 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.63 |
| ▸ | GABRP | O00591 | 1/20 | 0.63 |
| ▸ | GABRD | O14764 | 1/20 | 0.63 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.63 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.63 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.63 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.63 |
| ▸ | GABRE | P78334 | 1/20 | 0.63 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.63 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.63 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.63 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.63 |
| ▸ | CCNE2 | O96020 | 11/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 11/20 | 0.58 |
| ▸ | CDK2 | P24941 | 11/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meclonazepam SCHEMBL29365672 | 1.00 | GABRA1 (0.63) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| Meclonazepam SCHEMBL2109365 | 1.00 | GABRA1 (0.63) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11169561 | 0.88 | GABRP (0.59) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL2109368 | 0.88 | MEN1 (0.50) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11075550 | 0.87 | GABRA1 (0.48) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11081506 | 0.87 | GABRA1 (0.48) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11070068 | 0.87 | GABRA1 (0.48) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11465230 | 0.87 | GABRP (0.63) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL31365170 | 0.87 | LMNA (0.71) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11075724 | 0.86 | CCNE2 (0.60) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059386-B1 | IMIDAZODIAZEPINES, INTERMEDIATE PRODUCTS AND PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-09-18 | — | — | EP | claimed |
| EP-0059390-B1 | IMIDAZODIAZEPINES, INTERMEDIATE PRODUCTS AND PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-29 | — | — | EP | claimed |
| EP-0059388-B1 | IMIDAZODIAZEPINES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-29 | — | — | EP | claimed |
| EP-0059387-B1 | IMIDAZODIAZEPINES, PROCESS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | claimed |
| EP-0059389-B1 | IMIDAZODIAZEPINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-12-12 | — | — | EP | claimed |
| EP-0059386-A2 | Imidazodiazepines, intermediate products and process for their preparation, and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-08 | — | — | EP | claimed |
| EP-0059387-A2 | Imidazodiazepines, process and intermediate products for their preparation, and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-08 | — | — | EP | claimed |
| EP-0059388-A1 | Imidazodiazepines, process and intermediates for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-08 | — | — | EP | claimed |
| EP-0059390-A1 | Imidazodiazepines, intermediate products and process for their preparation, and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-08 | — | — | EP | claimed |
| EP-0059389-A1 | Imidazodiazepines, process for their preparation and medicines containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-08 | — | — | EP | claimed |
| EP-0027214-A1 | Imidazodiazepine derivatives, process and intermediates for their preparation, medicaments containing them and their therapeutic application | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-22 | — | — | EP | claimed |
| US-4046890-A | ENANTIOMORPHS, ANTHELMINTHIC, SEDATIVES, ANTI-CONVULSANTS, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1977-09-06 | — | — | US | claimed |
| EP-0059386-B1 | IMIDAZODIAZEPINES, INTERMEDIATE PRODUCTS AND PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-09-18 | — | — | EP | disclosed |
| EP-0059390-B1 | IMIDAZODIAZEPINES, INTERMEDIATE PRODUCTS AND PROCESS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-29 | — | — | EP | disclosed |
| EP-0059388-B1 | IMIDAZODIAZEPINES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-29 | — | — | EP | disclosed |
| EP-0059387-B1 | IMIDAZODIAZEPINES, PROCESS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION, AND MEDICINES CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | disclosed |
| EP-0027214-A1 | Imidazodiazepine derivatives, process and intermediates for their preparation, medicaments containing them and their therapeutic application | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-22 | — | — | EP | disclosed |
| EP-0027214-A1 | Imidazodiazepine derivatives, process and intermediates for their preparation, medicaments containing them and their therapeutic application | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-22 | — | — | EP | disclosed |
| US-4046890-A | ENANTIOMORPHS, ANTHELMINTHIC, SEDATIVES, ANTI-CONVULSANTS, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1977-09-06 | — | — | US | disclosed |
| US-4031078-A | ANTHELMINTICS, MUSCLE RELAXANTS, ANTICONVULSANTS | HOFFMANN-LA ROCHE INC. (US) | 1977-06-21 | — | — | US | disclosed |