Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | APP | P05067 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15223764 | 1.00 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| Diamfenetide SCHEMBL168664 | 0.94 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL92223 | 0.90 | ALDH1A1 (0.78) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL11111056 | 0.88 | ALDH1A1 (0.80) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL25395866 | 0.88 | KMT2A (0.71) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL10889365 | 0.88 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL12287264 | 0.88 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL23744956 | 0.86 | ALDH1A1 (0.68) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL14113146 | 0.86 | KMT2A (0.73) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL9795852 | 0.84 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170333567-A1 | Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers | SYNTARGA BV (NL) | 2017-11-23 | — | — | US | disclosed |
| US-9815784-B2 | CC-1065 analogs and their conjugates | SYNTARGA B.V. (NL) | 2017-11-14 | — | — | US | disclosed |
| US-20170274090-A1 | Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers | SYNTARGA BV (NL) | 2017-09-28 | — | — | US | disclosed |
| US-9629924-B2 | Conjugates of CC-1065 analogs and bifunctional linkers | SYNTARGA BV (NL) | 2017-04-25 | — | — | US | disclosed |
| US-20130224227-A1 | NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS | BYONDIS B.V. (NL) | 2013-08-29 | — | — | US | disclosed |
| US-20110207767-A1 | Novel cc-1065 Analogs and Their Conjugates | BYONDIS B.V. (NL) | 2011-08-25 | — | — | US | disclosed |
| US-4460588-A | NEMATOCIDES | ICI AUSTRALIA LIMITED (AU) | 1984-07-17 | — | — | US | disclosed |
| EP-0015124-B1 | PARASITICIDAL HETEROCYCLIC ETHER DERIVATIVES, PROCESSES FOR THE MANUFACTURE THEREOF AND COMPOSITIONS THEREOF | ICI AUSTRALIA LIMITED (AU) | 1983-06-01 | — | — | EP | disclosed |
| EP-0015124-A1 | Parasiticidal heterocyclic ether derivatives, processes for the manufacture thereof and compositions thereof | ICI AUSTRALIA LIMITED (AU) | 1980-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170274090-A1 | Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers | PCNA, DCLRE1A, CDC5L | ALDH1A1 2514/4885KMT2A 1026/4885MEN1 1237/4885 |
| US-20170333567-A1 | Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers | PCNA, DCLRE1A, CDC5L | ALDH1A1 2514/4885KMT2A 1026/4885MEN1 1237/4885 |
| US-20110207767-A1 | Novel cc-1065 Analogs and Their Conjugates | PCNA, CDC5L, TOP1 | ALDH1A1 2178/4885KMT2A 1087/4885MEN1 969/4885 |
| US-20130224227-A1 | NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS | PCNA, DCLRE1A, CDC5L | ALDH1A1 2514/4885KMT2A 1026/4885MEN1 1237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.