Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11111056 | 0.91 | ALDH1A1 (0.80) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL11070291 | 0.90 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL15223764 | 0.90 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL10802880 | 0.89 | ALDH1A1 (0.77) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL10457898 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL9570672 | 0.87 | ALDH1A1 (0.75) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL9570550 | 0.87 | ALDH1A1 (0.75) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL1133893 | 0.86 | KMT2A (0.74) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL3223930 | 0.86 | LMNA (0.74) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| Diamfenetide SCHEMBL168664 | 0.86 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060154954-A1 | Combinations and use of selected pharmaceutically active compounds | ALTANA PHARMA AG (DE) | 2006-07-13 | — | — | US | claimed |
| EP-1599175-A2 | IMIDAZOPYRIDINES CONTAINING COMBINATIONS AND THEIR USE IN TREATING GASTROINTESTINAL INFLAMMATORY DISORDERS | ALTANA Pharma AG (DE) | 2005-11-30 | — | — | EP | claimed |
| WO-2005074930-A1 | PHARMACEUTICAL COMBINATIONS OF (S) -PANTOPRAZOLE WITH NSAID OR CORTICOSTEROIDS | ALTANA PHARMA AG (DE) | 2005-08-18 | — | — | WO | claimed |
| US-20040242597-A1 | Combination | NYCOMED GMBH (DE) | 2004-12-02 | — | — | US | claimed |
| WO-2004071391-A2 | IMIDAZOPYRIDINES CONTAINING COMBINATIONS AND THEIR USE IN TREATING GASTROINTESTINAL INFLAMMATORY DISORDERS | ALTANA PHARMA AG (DE) | 2004-08-26 | — | — | WO | claimed |
| EP-1429807-A2 | COMBINATION OF A NSAID AND A PDE-4 INHIBITOR | ALTANA Pharma AG (DE) | 2004-06-23 | — | — | EP | claimed |
| WO-2003024489-A2 | COMBINATION OF A NSAID AND A PDE-4 INHIBITOR | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | claimed |
| WO-1999001607-A2 | ENZYMATIC OXIDATION SYSTEM WITH NOVEL ENZYMATIC-EFFECT ENHANCING COMPOUNDS | CALL, KRIMHILD (DE) | 1999-01-14 | — | — | WO | claimed |
| US-4014921-A | ANALGESICS, ANTIPYRETIC, ANTIINFLAMMATORY | ALTER, S.A. (ES) | 1977-03-29 | — | — | US | claimed |
| US-20170182047-A9 | Post-Translational Regulation of Catalytic Activities of Cytochrome P450 46A1 and Uses Thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-06-29 | — | — | US | disclosed |
| US-20140073652-A1 | Post-Translational Regulation of Catalytic Activities of Cytochrome P450 46A1 and Uses Thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-03-13 | — | — | US | disclosed |
| US-8242146-B2 | Administering ROFLUMILAS and DICLOFENAC; antiinflammatory agents | NYCOMED GMBH (DE) | 2012-08-14 | — | — | US | disclosed |
| US-8129308-B2 | Thermal transfer image-receiving sheet and surface condition improver | FUJIFILM CORPORATION (JP) | 2012-03-06 | — | — | US | disclosed |
| EP-1820503-B1 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | PFIZER ITALIA SRL (IT) | 2012-02-22 | — | — | EP | disclosed |
| EP-0015124-B1 | PARASITICIDAL HETEROCYCLIC ETHER DERIVATIVES, PROCESSES FOR THE MANUFACTURE THEREOF AND COMPOSITIONS THEREOF | ICI AUSTRALIA LIMITED (AU) | 1983-06-01 | — | — | EP | disclosed |
| EP-0015124-A1 | Parasiticidal heterocyclic ether derivatives, processes for the manufacture thereof and compositions thereof | ICI AUSTRALIA LIMITED (AU) | 1980-09-03 | — | — | EP | disclosed |
| US-4014921-A | ANALGESICS, ANTIPYRETIC, ANTIINFLAMMATORY | ALTER, S.A. (ES) | 1977-03-29 | — | — | US | disclosed |
| US-4014921-A | ANALGESICS, ANTIPYRETIC, ANTIINFLAMMATORY | ALTER, S.A. (ES) | 1977-03-29 | — | — | US | disclosed |
| US-4014921-A | ANALGESICS, ANTIPYRETIC, ANTIINFLAMMATORY | ALTER, S.A. (ES) | 1977-03-29 | — | — | US | disclosed |
| US-3957999-A | ADMINISTERING | THE BOOTS COMPANY (EN) | 1976-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073652-A1 | Post-Translational Regulation of Catalytic Activities of Cytochrome P450 46A1 and Uses Thereof | CYP46A1, CYP11A1, CYP27A1 | ALDH1A1 1724/4885KMT2A 3468/4885MEN1 4409/4885 |
| US-20170182047-A9 | Post-Translational Regulation of Catalytic Activities of Cytochrome P450 46A1 and Uses Thereof | CYP46A1, CYP11A1, CYP27A1 | ALDH1A1 1724/4885KMT2A 3468/4885MEN1 4409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.