Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM2 | O94759 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10959357 | 0.76 | MAPT (0.46) | TRPM2KDM4EALDH1A1MAPK1POLB | |
| SCHEMBL2363647 | 0.73 | SCN9A (0.46) | KDM4EALDH1A1GAAMAPK1POLB | |
| SCHEMBL2362965 | 0.72 | SCN9A (0.45) | KDM4EALDH1A1GAAMAPK1POLB | |
| SCHEMBL10958614 | 0.71 | RORB (0.44) | ALDH1A1MAPK1CFTRMAPTNPC1 | |
| SCHEMBL17163996 | 0.70 | GAA (0.44) | KDM4EALDH1A1GAAMAPK1MAPT | |
| SCHEMBL2471294 | 0.70 | PLAU (0.47) | ALDH1A1GAACFTRMAPTDHODH | |
| SCHEMBL11000009 | 0.70 | ALDH1A1 (0.55) | KDM4EALDH1A1GAAMAPK1CFTR | |
| SCHEMBL27006451 | 0.69 | LMNA (0.51) | KDM4EALDH1A1GAAMAPK1POLB | |
| SCHEMBL4051093 | 0.69 | LMNA (0.51) | KDM4EALDH1A1MAPK1MAPTKMT2A | |
| SCHEMBL22777430 | 0.69 | PTGER4 (0.39) | KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112623-A2 | 3-Aryl-5-pyrazole-carboxylic-acid derivatives, their preparation and pharmaceutical compositions | ELI LILLY AND COMPANY (US) | 1984-07-04 | — | — | EP | disclosed |