Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 6/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL11060156 | 0.90 | SLC18A3 (0.45) | ABCB1HTR6ADRB2ADRB1ADRB3 | |
| SCHEMBL11065039 | 0.83 | DRD4 (0.60) | ABCB1DRD4DRD2ADRB2ADRB1 | |
| Oxalic Acid SCHEMBL11071627 | 0.81 | ABCB1 (0.58) | ABCB1DRD4DRD2ADRB2ADRB1 | |
| SCHEMBL11729211 | 0.79 | HTR6 (0.48) | ABCB1HTR6KMT2AMEN1POLB | |
| Iodide SCHEMBL11071830 | 0.79 | SLC18A3 (0.44) | ABCB1DRD4DRD2ADRB2ADRB1 | |
| SCHEMBL11066891 | 0.78 | ABCB1 (0.61) | ABCB1DRD4DRD2ADRB2ADRB1 | |
| SCHEMBL11071631 | 0.77 | DRD4 (0.49) | ABCB1DRD4DRD2ADRB2ADRB1 | |
| Oxalic Acid SCHEMBL11067627 | 0.76 | ABCB1 (0.61) | ABCB1DRD4DRD2ADRB2ADRB1 | |
| SCHEMBL11061136 | 0.74 | KCNH2 (0.56) | ABCB1DRD4DRD2ADRB2ADRB1 | |
| SCHEMBL10570390 | 0.74 | MAPT (0.56) | ABCB1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482560-A | Carbostyril derivatives, and antihistaminic agents containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-13 | — | — | US | disclosed |