Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL11060156 | 0.89 | SLC18A3 (0.45) | SLC18A3ADRB2ADRB1ADRB3KCNH2 | |
| SCHEMBL11064919 | 0.83 | ADRB2 (0.51) | SLC18A3ADRB2ADRB1ADRB3KCNH2 | |
| Oxalic Acid SCHEMBL11068715 | 0.81 | KCNH2 (0.50) | ADRB2ADRB1ADRB3KCNH2ABCB1 | |
| Iodide SCHEMBL11071282 | 0.79 | ABCB1 (0.41) | ADRB2ADRB1ADRB3ABCB1DRD2 | |
| SCHEMBL11724290 | 0.78 | ABCB1 (0.41) | ADRB2ADRB1ADRB3ABCB1LOXL2 | |
| SCHEMBL11068716 | 0.77 | SLC18A3 (0.42) | SLC18A3ADRB2ADRB1ADRB3KCNH2 | |
| Iodide SCHEMBL11065747 | 0.77 | ADRB1 (0.54) | SLC18A3ADRB2ADRB1KCNH2APOBEC3A | |
| SCHEMBL11062978 | 0.77 | ADRB2 (0.46) | ADRB2ADRB1ADRB3KCNH2ABCB1 | |
| SCHEMBL11068290 | 0.77 | ABCB1 (0.40) | ADRB2ADRB1ADRB3ABCB1LOXL2 | |
| SCHEMBL10572085 | 0.75 | MAPT (0.59) | ADRB2ADRB1ADRB3ABCB1SCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482560-A | Carbostyril derivatives, and antihistaminic agents containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-13 | — | — | US | disclosed |