Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | CASR | P41180 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11751333 | 0.84 | HTR1A (0.65) | MEN1KMT2AALDH1A1HTR1AADRA2A | |
| SCHEMBL11200218 | 0.83 | HTR2B (0.70) | ALDH1A1HTR1AADRA2AADRA2BMAOA | |
| SCHEMBL11207616 | 0.81 | HTR1A (0.67) | MEN1KMT2AALDH1A1HTR1AADRA2A | |
| SCHEMBL11469815 | 0.81 | HTR1A (0.63) | MEN1KMT2AALDH1A1HTR1AADRA2A | |
| SCHEMBL11073795 | 0.81 | MEN1 (0.68) | MEN1KMT2AALDH1A1ADRB2ADRB3 | |
| SCHEMBL11499698 | 0.80 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1HTR1AADRA2A | |
| SCHEMBL11245319 | 0.80 | ALDH1A1 (0.67) | MEN1KMT2AALDH1A1HTR1AADRA2A | |
| SCHEMBL11748169 | 0.79 | HTR1A (0.68) | MEN1KMT2AALDH1A1HTR1AADRA2A | |
| SCHEMBL11074646 | 0.79 | MEN1 (0.65) | MEN1KMT2AALDH1A1HTR2BADRB2 | |
| SCHEMBL11079509 | 0.79 | ALDH1A1 (0.65) | MEN1KMT2AALDH1A1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4450115-A | ADRENERGIC BLOCKING AGENTS; HYPOTENSIVE AND CARDIOTONIC AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1984-05-22 | — | — | US | claimed |
| US-4450115-A | ADRENERGIC BLOCKING AGENTS; HYPOTENSIVE AND CARDIOTONIC AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1984-05-22 | — | — | US | disclosed |
| US-4381398-A | Amino-alcohol derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-04-26 | — | — | US | disclosed |