SCHEMBL11207616

SCHEMBL11207616

CC(N)NCC(O)COc1ccccc1C#N

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 1/20 0.67
ADRA2A P08913 1/20 0.67
ADRA2B P18089 1/20 0.67
MAOA P21397 1/20 0.67
HTR2B P41595 1/20 0.67
ADRB2 P07550 5/20 0.54
CYP2D6 P10635 4/20 0.54
CASR P41180 4/20 0.54
ADRB3 P13945 3/20 0.54
SLC6A2 P23975 2/20 0.54
SLC6A4 P31645 2/20 0.54
SLC6A3 Q01959 2/20 0.54
KCNH2 Q12809 2/20 0.54
ADRB1 P08588 7/20 0.52
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
KDM4E B2RXH2 1/20 0.52
CYP1A2 P05177 1/20 0.52
ALOX15 P16050 1/20 0.52
ALDH1A1 P00352 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11200218 0.89 HTR2B (0.70) HTR1AADRA2AADRA2BMAOAHTR2B
SCHEMBL11751333 0.86 HTR1A (0.65) HTR1AADRA2AADRA2BMAOAHTR2B
SCHEMBL11748169 0.83 HTR1A (0.68) HTR1AADRA2AADRA2BMAOAHTR2B
SCHEMBL9655212 0.81 HTR1A (0.70) HTR1AADRA2AADRA2BMAOAHTR2B
SCHEMBL11751117 0.81 HTR1A (0.62) HTR1AADRA2AADRA2BMAOAHTR2B
SCHEMBL11071495 0.81 MEN1 (0.67) HTR1AADRA2AADRA2BMAOAHTR2B
SCHEMBL11803062 0.81 ADRB1 (0.72) HTR1AADRA2AADRA2BMAOAHTR2B
SCHEMBL10738067 0.81 ADRB2 (0.78) HTR1AADRA2AHTR2BADRB2CYP2D6
SCHEMBL10743558 0.81 CYP1A2 (0.60) HTR1AADRA2AHTR2BADRB2CYP2D6
Bunitrolol SCHEMBL34721 0.80 HTR1A (1.00) HTR1AADRA2AADRA2BMAOAHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4387099-A Alkanolamine derivatives IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1983-06-07 US disclosed
US-4327113-A DRUGS FOR TREATMENT OF HEART DISEASES, ADRENERGIC BLOCKING AGENTS, ETC IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-04-27 US disclosed
US-4260632-A ADRENERGIC BLOCKING AGENTS, CARDIOVASCULAR DISORDERS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-04-07 US disclosed
US-4221807-A ADRENERGIC BLOCKING AGENTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-09-09 US disclosed
US-4141987-A HYPOTENSIVE, ADRENERGIC BLOCKING AGENT IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-02-27 US disclosed