Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 4/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068985 | 0.89 | CNR1 (0.50) | CNR1CNR2ADORA1PDE1APDE1B | |
| SCHEMBL11081687 | 0.88 | CNR1 (0.59) | CNR1CNR2ADORA1PDE1APDE1B | |
| SCHEMBL11071848 | 0.84 | CNR1 (0.57) | CNR1CNR2ADORA1PDE1APDE1B | |
| SCHEMBL10973972 | 0.83 | CNR1 (0.57) | CNR1CNR2ADORA1PDE1APDE1B | |
| SCHEMBL11070514 | 0.83 | CNR1 (0.57) | CNR1CNR2ADORA1PDE1APDE1B | |
| SCHEMBL11074709 | 0.83 | CNR1 (0.56) | CNR1CNR2ADORA1PDE1APDE1B | |
| SCHEMBL11079598 | 0.83 | CNR1 (0.56) | CNR1CNR2ADORA1PDE1APDE1B | |
| SCHEMBL10972776 | 0.81 | CNR1 (0.54) | CNR1CNR2ADORA1PDE1APDE1B | |
| SCHEMBL11340568 | 0.81 | CNR1 (0.52) | CNR1CNR2ADORA1PDE1APDE1B | |
| SCHEMBL11076274 | 0.81 | CNR1 (0.48) | CNR1CNR2ADORA1PDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451467-A | HYPOTENSIVE AGENTS | Ishikawa, Masayuki (JP) | 1984-05-29 | — | — | US | disclosed |
| EP-0056637-A1 | 4(3H)-quinazolinone derivatives, process for production thereof and pharmaceutical compositions comprising said compounds | Ishikawa, Masayuki (JP) | 1982-07-28 | — | — | EP | disclosed |