Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.46 |
| ▸ | MMP9 | P14780 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1152677 | 0.86 | OPRM1 (0.49) | MAPTKMT2AKCNH2OPRM1SLC22A1 | |
| SCHEMBL10641018 | 0.84 | POLB (0.42) | MAPTPOLBSMN1; SMN2OPRM1DRD4 | |
| SCHEMBL11074351 | 0.84 | SLC6A4 (0.43) | MMP9MAPTKMT2AMMP1CCR6 | |
| SCHEMBL10640876 | 0.79 | OPRM1 (0.49) | KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL10637592 | 0.77 | OPRM1 (0.46) | MAPTKMT2ALMNASMN1; SMN2KCNH2 | |
| SCHEMBL10637222 | 0.77 | OPRM1 (0.50) | MAPTPOLBKMT2ALMNAKCNH2 | |
| SCHEMBL10634827 | 0.76 | KMT2A (0.58) | KMT2AGAASMN1; SMN2OPRM1SLC6A4 | |
| SCHEMBL10637675 | 0.75 | KDM4E (0.42) | KMT2ALMNAOPRM1HRH4 | |
| SCHEMBL11068281 | 0.75 | ALDH1A1 (0.43) | MAPTPOLBKMT2ASMN1; SMN2SLC6A4 | |
| SCHEMBL11074405 | 0.75 | OPRL1 (0.39) | MAPTSMN1; SMN2OPRM1OPRD1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4485109-A | 4-Aryl-4-piperidinecarbinols | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-11-27 | — | — | US | disclosed |
| EP-0094018-A2 | 4-Aryl-4-piperidinecarbinols | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-11-16 | — | — | EP | disclosed |