Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10640876 | 0.82 | OPRM1 (0.49) | OPRL1CYP1A2OPRM1OPRD1 | |
| SCHEMBL10637592 | 0.81 | OPRM1 (0.46) | DRD2ALDH1A1KDM4EMAPTCYP2D6 | |
| SCHEMBL10637222 | 0.81 | OPRM1 (0.50) | DRD2ALDH1A1MAPTOPRM1 | |
| SCHEMBL1152677 | 0.80 | OPRM1 (0.49) | DRD2ALDH1A1TSHRMAPTOPRM1 | |
| SCHEMBL11068281 | 0.78 | ALDH1A1 (0.43) | CCR1DRD2HSD17B10ALDH1A1TSHR | |
| SCHEMBL10641018 | 0.78 | POLB (0.42) | TSHRMAPTMAPK1SMN1; SMN2OPRM1 | |
| SCHEMBL11074351 | 0.78 | SLC6A4 (0.43) | OPRL1CYP3A4MAPTCYP2C19OPRM1 | |
| SCHEMBL11073037 | 0.75 | MMP2 (0.46) | MAPTSMN1; SMN2HRH4OPRM1OPRD1 | |
| SCHEMBL5754493 | 0.72 | CHRM1 (0.37) | DRD2HRH4OPRM1OPRD1 | |
| SCHEMBL11075430 | 0.71 | OPRD1 (0.44) | OPRL1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4485109-A | 4-Aryl-4-piperidinecarbinols | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-11-27 | — | — | US | disclosed |
| EP-0094018-A2 | 4-Aryl-4-piperidinecarbinols | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-11-16 | — | — | EP | disclosed |