SCHEMBL11073604

SCHEMBL11073604

COc1ccc(OC)c(S(=O)(=O)NC(=O)Nc2nc(OC)nc(OC)n2)c1

nearest known ligand 0.54

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.52
MAPT P10636 3/20 0.51
SMN1; SMN2 Q16637 2/20 0.50
ALPL P05186 2/20 0.46
KMT2A Q03164 2/20 0.46
GAA P10253 2/20 0.46
MEN1 O00255 1/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
HTT P42858 1/20 0.46
STS P08842 1/20 0.46
MAPK1 P28482 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11638047 0.81 KDM4E (0.46) MAPTKMT2AGAAKDM4EALDH1A1
SCHEMBL10853805 0.80 CDK1 (0.43) MAPTGAAKDM4EALDH1A1HTT
SCHEMBL6535353 0.80 CDK1 (0.43) MAPTKMT2AGAAMEN1KDM4E
SCHEMBL10913706 0.80 GAA (0.41) MAPTKMT2AGAAMEN1KDM4E
SCHEMBL11067484 0.79 TSHR (0.47) L3MBTL1MAPTSMN1; SMN2ALPLKMT2A
SCHEMBL2994281 0.78 KDM4E (0.47) MAPTSMN1; SMN2KMT2AGAAKDM4E
SCHEMBL5960084 0.77 MAPT (0.54) L3MBTL1MAPTSMN1; SMN2KMT2AGAA
SCHEMBL9814932 0.77 ALDH1A1 (0.47) MAPTSMN1; SMN2GAAKDM4EALDH1A1
SCHEMBL11002896 0.77 MAPT (0.47) MAPTGAAKDM4EALDH1A1
SCHEMBL10889026 0.77 ALDH1A1 (0.50) MAPTSMN1; SMN2GAAKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4127405-A TRIAZINYL E. I. DU PONT DE NEMOURS AND COMPANY (US) 1978-11-28 US claimed
EP-0001514-B1 HERBICIDAL SULFONAMIDES, AND PREPARATION AND USE THEREOF E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-08-08 EP disclosed
US-4443244-A TRIAZINES AND PYRIMIDINES, PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-17 US disclosed
US-4339266-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1982-07-13 US disclosed
EP-0001514-A2 Herbicidal sulfonamides, and preparation and use thereof E.I. DU PONT DE NEMOURS AND COMPANY (US) 1979-04-18 EP disclosed
US-4127405-A TRIAZINYL E. I. DU PONT DE NEMOURS AND COMPANY (US) 1978-11-28 US disclosed