Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 14/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1865137 | 0.89 | GCK (0.58) | GCKKMT2AEPHX1MEN1KCNH2 | |
| SCHEMBL1865136 | 0.89 | GCK (0.58) | GCKKMT2AEPHX1MEN1KCNH2 | |
| SCHEMBL2646260 | 0.87 | GCK (0.57) | GCKKMT2AEPHX1MEN1KCNH2 | |
| SCHEMBL2650823 | 0.87 | GCK (0.57) | GCKKMT2AEPHX1MEN1KCNH2 | |
| SCHEMBL2646180 | 0.87 | GCK (0.57) | GCKKMT2AEPHX1MEN1KCNH2 | |
| SCHEMBL2667236 | 0.87 | GCK (0.57) | GCKKMT2AEPHX1KCNH2 | |
| SCHEMBL2897166 | 0.87 | GCK (0.57) | GCKKMT2AMEN1KCNH2 | |
| SCHEMBL1107300 | 0.86 | GCK (0.56) | GCKKMT2AEPHX1KCNH2 | |
| SCHEMBL13477802 | 0.86 | GCK (0.56) | GCKKMT2AEPHX1KCNH2 | |
| SCHEMBL12594351 | 0.86 | GCK (0.45) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170087160-A1 | USES OF DPP IV INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2017-03-30 | — | — | US | disclosed |
| US-20160000798-A1 | USES OF DPP IV INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2016-01-07 | — | — | US | disclosed |
| US-9173859-B2 | Uses of DPP IV inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-20140135348-A1 | USES OF DPP IV INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-15 | — | — | US | disclosed |
| US-8673927-B2 | Uses of DPP-IV inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-03-18 | — | — | US | disclosed |
| US-8232281-B2 | Uses of DPP-IV inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-07-31 | — | — | US | disclosed |
| US-8153677-B2 | Substituted pyrazolylamide compounds useful as glucokinase activators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153677-B2 | Substituted pyrazolylamide compounds useful as glucokinase activators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-10 | — | — | US | disclosed |
| US-20110118211-A1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | BRISTOL-MYERS SQUIBB COMPANY | 2011-05-19 | — | — | US | disclosed |
| US-20110118211-A1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | BRISTOL-MYERS SQUIBB COMPANY | 2011-05-19 | — | — | US | disclosed |
| US-7910747-B2 | Phosphonate and phosphinate pyrazolylamide glucokinase activators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-03-22 | — | — | US | disclosed |
| US-20110065731-A1 | USES OF DPP-IV INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-17 | — | — | US | disclosed |
| US-7888504-B2 | Glucokinase activators and methods of using same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-15 | — | — | US | disclosed |
| US-20080021052-A1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | BRISTOL-MYERS SQUIBB COMPANY | 2008-01-24 | — | — | US | disclosed |
| US-20080009465-A1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | BRISTOL-MYERS SQUIBB COMPANY | 2008-01-10 | — | — | US | disclosed |
| US-20080009465-A1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | BRISTOL-MYERS SQUIBB COMPANY | 2008-01-10 | — | — | US | disclosed |
| WO-2008005964-A2 | PHOSPHONATE AND PHOSPHINATE COMPOUNDS AS GLUCOKINASE ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | disclosed |
| US-20070281940-A1 | USES OF DPP-IV INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160000798-A1 | USES OF DPP IV INHIBITORS | DPP4, DPP3, DPP7 | GCK 68/4885KMT2A 3365/4885EPHX1 1921/4885 |
| US-20170087160-A1 | USES OF DPP IV INHIBITORS | DPP4, DPP3, DPP7 | GCK 68/4885KMT2A 3365/4885EPHX1 1921/4885 |
| US-20110118211-A1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | GCKR, MPO, GCK | GCK 3/4885KMT2A 2216/4885EPHX1 3148/4885 |
| US-20070281940-A1 | USES OF DPP-IV INHIBITORS | DPP4, DPP3, DPP7 | GCK 63/4885KMT2A 3259/4885EPHX1 1958/4885 |
| US-20110065731-A1 | USES OF DPP-IV INHIBITORS | DPP4, DPP3, DPP7 | GCK 63/4885KMT2A 3259/4885EPHX1 1958/4885 |
| US-20080009465-A1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | GCKR, GCK, PCK1 | GCK 2/4885KMT2A 2344/4885EPHX1 3662/4885 |
| US-20140135348-A1 | USES OF DPP IV INHIBITORS | DPP4, DPP3, DPP7 | GCK 68/4885KMT2A 3365/4885EPHX1 1921/4885 |
| US-20080021052-A1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | GCKR, GCK, NR4A3 | GCK 2/4885KMT2A 2341/4885EPHX1 4559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.