Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.46 |
| ▸ | WNT3A | P56704 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519876 | 0.86 | LMNA (0.58) | LMNAGAACTNNB1WNT3ACNR2 | |
| SCHEMBL1405144 | 0.86 | LMNA (0.58) | LMNAGAACTNNB1WNT3ACNR2 | |
| SCHEMBL27570825 | 0.84 | LMNA (0.56) | LMNAGAACTNNB1WNT3ACNR2 | |
| SCHEMBL45490 | 0.82 | LMNA (0.59) | LMNAGAA | |
| SCHEMBL28284599 | 0.82 | LMNA (0.55) | LMNAGAACTNNB1WNT3ACNR2 | |
| SCHEMBL513905 | 0.82 | LMNA (0.55) | LMNAGAACTNNB1WNT3ACNR2 | |
| SCHEMBL14976 | 0.80 | MAPT (0.44) | LMNAGAATDP1NPC1 | |
| SCHEMBL29448528 | 0.80 | MAPT (0.44) | LMNAGAATDP1NPC1 | |
| SCHEMBL6675290 | 0.79 | LMNA (0.51) | LMNAGAACTNNB1WNT3ACNR2 | |
| SCHEMBL2863943 | 0.79 | LMNA (0.51) | LMNAGAACTNNB1WNT3ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4431590-A | 1-Chlorosulphonyl-2,3,4,10-tetrahydro-1H-chromeno[3,4-c]azet-2-one | HOFFMANN-LA ROCHE INC. (US) | 1984-02-14 | — | — | US | disclosed |
| US-4322360-A | Process for producing imidazolidone intermediates of biotin | HOFFMANN-LA ROCHE INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4284788-A | Imidazolidone intermediates of biotin | HOFFMANN-LA ROCHE INC. (US) | 1981-08-18 | — | — | US | disclosed |
| EP-0022446-A1 | Process for the preparation of biotin esters and biotin | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-01-21 | — | — | EP | disclosed |