Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 9/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11071372 | 0.87 | OPRL1 (0.39) | OPRL1HTR2AHTR2CSLC6A4HTR2B | |
| SCHEMBL11073165 | 0.81 | OPRL1 (0.34) | OPRL1HTR2AHTR2CSLC6A4HTR2B | |
| SCHEMBL11066524 | 0.77 | MLNR (0.37) | OPRL1HTR2AHTR2CTACR1SLC6A4 | |
| SCHEMBL11071936 | 0.76 | SLC6A4 (0.39) | OPRL1HTR2AHTR2CSLC6A4OPRM1 | |
| SCHEMBL11071916 | 0.73 | OPRM1 (0.38) | OPRL1OPRM1IRAK4 | |
| SCHEMBL10263785 | 0.72 | GRIN2B (0.42) | HTR2CSLC6A4HTR2B | |
| SCHEMBL11072284 | 0.72 | PARP1 (0.33) | HTR2AHTR2CHTR2B | |
| SCHEMBL11070178 | 0.72 | OPRL1 (0.51) | OPRL1HTR2AHTR2CTACR1SLC6A4 | |
| Ethylbenzene SCHEMBL11069833 | 0.71 | OPRL1 (0.47) | OPRL1TACR1SLC6A4OPRM1 | |
| SCHEMBL11069827 | 0.70 | GRIN2B (0.42) | OPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447454-A | Analgetic compounds, compositions and process of treatment | THE UPJOHN COMPANY (US) | 1984-05-08 | — | — | US | disclosed |
| US-4113866-A | ANALGETIC COMPOUNDS, COMPOSITIONS AND PROCESS OF TREATMENT | THE UPJOHN COMPANY (US) | 1978-09-12 | — | — | US | disclosed |