SCHEMBL11076064

SCHEMBL11076064

CCN(CC)C(=O)Cc1ccc(O)c(C(C)(C)C)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 4/20 0.60
HSP90AB1 P08238 4/20 0.60
LMNA P02545 3/20 0.45
RECQL P46063 1/20 0.45
ALDH1A1 P00352 4/20 0.43
HSD17B10 Q99714 2/20 0.43
ALOX15 P16050 2/20 0.43
NR1I2 O75469 1/20 0.43
CYP2C9 P11712 1/20 0.43
MIF P14174 1/20 0.43
TYR P14679 1/20 0.43
HTT P42858 1/20 0.43
NFE2L2 Q16236 1/20 0.43
TDP1 Q9NUW8 3/20 0.39
POLB P06746 2/20 0.39
APEX1 P27695 2/20 0.39
GAA P10253 2/20 0.39
XBP1 P17861 1/20 0.39
ATM Q13315 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8149589 0.83 LMNA (0.61) HSP90AA1HSP90AB1LMNARECQLALDH1A1
SCHEMBL10948201 0.82 TSHR (0.56) HSP90AA1HSP90AB1LMNAHSD17B10ALOX15
SCHEMBL7792132 0.79 HSD17B10 (0.61) HSP90AA1HSP90AB1LMNAALDH1A1HSD17B10
SCHEMBL6115630 0.78 POLB (0.47) HSP90AA1HSP90AB1LMNAALDH1A1HSD17B10
SCHEMBL8747630 0.78 ALDH1A1 (0.48) HSP90AA1HSP90AB1LMNAALDH1A1HSD17B10
SCHEMBL7943239 0.77 HSP90AA1 (0.51) HSP90AA1HSP90AB1LMNARECQLALDH1A1
SCHEMBL11079181 0.76 HSP90AA1 (0.60) HSP90AA1HSP90AB1TDP1POLBAPEX1
SCHEMBL8606388 0.75 HSP90AA1 (0.40) HSP90AA1HSP90AB1LMNAALDH1A1HSD17B10
SCHEMBL5086740 0.75 GAA (0.50) HSP90AA1HSP90AB1LMNAALDH1A1HSD17B10
SCHEMBL487668 0.75 HSP90AA1 (1.00) HSP90AA1HSP90AB1LMNARECQLALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4435397-A ADRENERGIC BLOCKING AGENTS, 4-(3-ARYLOXY-2-HYDROXYPROPYL) SUBSTITUTED NIPPON SHINYAKU CO., LTD. (JP) 1984-03-06 US disclosed