Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 9/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11077003 | 0.88 | GABRA1 (0.53) | PTAFRGABRA5GABRA2GABRB2GABRA1 | |
| SCHEMBL11076943 | 0.87 | BRD4 (0.52) | GABRA5GABRA2GABRB2GABRA1GABRG2 | |
| SCHEMBL11730100 | 0.78 | PTAFR (0.76) | PTAFRGABRA5GABRA2GABRB2GABRA1 | |
| SCHEMBL7327273 | 0.76 | OPRK1 (0.66) | GABRA5GABRA2GABRB2GABRA1GABRG2 | |
| SCHEMBL11073512 | 0.75 | PTAFR (0.53) | PTAFRGABRA5GABRA2GABRB2GABRA1 | |
| SCHEMBL11607865 | 0.75 | PTAFR (0.51) | PTAFRGABRA5GABRA2GABRB2GABRA1 | |
| SCHEMBL11718798 | 0.75 | PTAFR (0.50) | PTAFRGABRA5GABRA2GABRB2GABRA1 | |
| SCHEMBL5354780 | 0.75 | BRD4 (0.52) | GABRA5GABRA2GABRB2GABRA1GABRG2 | |
| SCHEMBL11603427 | 0.74 | PTAFR (0.50) | PTAFRGABRA5GABRA2GABRB2GABRA1 | |
| SCHEMBL11713949 | 0.74 | PTAFR (0.52) | PTAFRGABRA5GABRA2GABRB2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4427590-A | Triazolobenzodiazepine derivatives | CIBA-GEIGY CORPORATION (US) | 1984-01-24 | — | — | US | disclosed |