Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.54 |
| ▸ | RB1 | P06400 | 3/20 | 0.52 |
| ▸ | DRD1 | P21728 | 3/20 | 0.49 |
| ▸ | DRD5 | P21918 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8579183 | 0.84 | RB1 (0.63) | NR2E1RB1DRD1DRD5DRD2 | |
| SCHEMBL2515919 | 0.84 | NR2E1 (0.67) | NR2E1RB1DRD1DRD5DRD2 | |
| SCHEMBL26837000 | 0.82 | NR2E1 (0.59) | NR2E1RB1DRD1DRD5KDM4E | |
| SCHEMBL21754369 | 0.79 | NR2E1 (0.75) | NR2E1RB1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL5229700 | 0.78 | MEN1 (0.47) | NR2E1RB1KDM4EALDH1A1CYP2D6 | |
| SCHEMBL11453237 | 0.77 | KDM4E (0.59) | NR2E1DRD1DRD5DRD2DRD4 | |
| SCHEMBL11858668 | 0.77 | KDM4E (0.49) | NR2E1RB1DRD1DRD5DRD2 | |
| SCHEMBL13751060 | 0.77 | NR2E1 (0.50) | NR2E1RB1DRD1DRD5DRD2 | |
| SCHEMBL29611826 | 0.77 | KDM4E (0.59) | NR2E1DRD1DRD5DRD2DRD4 | |
| SCHEMBL13923541 | 0.77 | KDM4E (0.59) | NR2E1DRD1DRD5DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206156-B2 | Substituted indole derivatives | Grünenthal GmbH (DE) | 2015-12-08 | — | — | US | disclosed |
| US-20130116283-A1 | Substituted indole derivatives | Grünenthal GmbH (DE) | 2013-05-09 | — | — | US | disclosed |
| EP-1848426-B1 | TRICYCLIC CYTOPROTECTIVE COMPOUNDS | HUNTER FLEMING LTD (GB) | 2012-08-01 | — | — | EP | disclosed |
| US-4436917-A | REACTION OF ANILINE AND GLYCOL, CATALYST | MITSUI TOATSU CHEMICALS, INC. (JP) | 1984-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116283-A1 | Substituted indole derivatives | IDO1, IDO2, TPH1 | NR2E1 2616/4885RB1 1973/4885DRD1 815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.