Quinoline

Quinoline

SCHEMBL11076491

C=CCc1ccc2ccccc2n1.c1ccc2ncccc2c1

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.55
PDE10A Q9Y233 1/20 0.52
CYSLTR1 Q9Y271 2/20 0.45
CYSLTR2 Q9NS75 1/20 0.45
HTT P42858 2/20 0.41
KDM4E B2RXH2 1/20 0.41
NPC1 O15118 1/20 0.41
TP53 P04637 1/20 0.41
HPGD P15428 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HSD17B10 Q99714 1/20 0.41
CYP3A4 P08684 2/20 0.40
CYP1A2 P05177 2/20 0.39
MEN1 O00255 1/20 0.39
CASP1 P29466 1/20 0.39
CASP7 P55210 1/20 0.39
KMT2A Q03164 1/20 0.39
CYP2C19 P33261 1/20 0.39
NR4A2 P43354 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL322184 0.90 CYSLTR1 (0.49) PDE10ACYSLTR1CYSLTR2CYP1A2GPBAR1
SCHEMBL27856432 0.88 CYSLTR1 (0.47) PDE10ACYSLTR1CYSLTR2CYP1A2GPBAR1
Bromide SCHEMBL28854191 0.88 CYSLTR1 (0.47) PDE10ACYSLTR1CYSLTR2CYP1A2GPBAR1
Hydrogen Sulfide SCHEMBL27881046 0.88 CYSLTR1 (0.47) PDE10ACYSLTR1CYSLTR2CYP1A2GPBAR1
Hydrochloric Acid SCHEMBL27834787 0.88 CYSLTR1 (0.47) PDE10ACYSLTR1CYSLTR2CYP1A2GPBAR1
Quinoline SCHEMBL27518259 0.85 ALDH1A1 (0.57) ALDH1A1PDE10AHTTKDM4ENPC1
Quinoline SCHEMBL28225919 0.79 ALDH1A1 (0.49) ALDH1A1PDE10AHTTKDM4ENPC1
SCHEMBL27956726 0.78 PDE10A (0.40) ALDH1A1PDE10ACYSLTR1CYSLTR2KDM4E
SCHEMBL167042 0.78 ALDH1A1 (0.47) ALDH1A1PDE10AHTTKDM4ETP53
Quinoline SCHEMBL28850528 0.78 ALDH1A1 (0.61) ALDH1A1PDE10ACYSLTR1CYSLTR2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105745300-B Method of consolidating solid materials during subterranean treatment operations 韦特福特科技控股有限责任公司 2019-10-22 CN disclosed
CN-106170527-A For producing the method and system in high flow conductivity crack 路博润油田解决方案公司 2016-11-30 CN disclosed
US-4444668-A Well completion fluid compositions HALLIBURTON COMPANY (US) 1984-04-24 US disclosed