Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 13/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.44 |
| ▸ | PHLPP1 | O60346 | 3/20 | 0.44 |
| ▸ | ILK | Q13418 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11075163 | 0.87 | AKT1 (0.46) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL11244215 | 0.82 | AKT1 (0.50) | AKT1PDPK1PHLPP1ILKLMNA | |
| SCHEMBL11075657 | 0.81 | LMNA (0.42) | LMNAHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL11078511 | 0.80 | POLB (0.41) | AKT1PDPK1PHLPP1ILKLMNA | |
| SCHEMBL9094646 | 0.78 | AKT1 (0.67) | AKT1PDPK1PHLPP1ILKLMNA | |
| SCHEMBL11081507 | 0.74 | AKT1 (0.70) | AKT1PDPK1PHLPP1ILKLMNA | |
| SCHEMBL27456056 | 0.73 | HTR1A (0.39) | AKT1PDPK1PHLPP1ILKHTR1A | |
| SCHEMBL9749197 | 0.73 | SSTR5 (0.37) | AKT1LMNAHTR1AHTR1BHTR2A | |
| SCHEMBL8747767 | 0.70 | MAPT (0.63) | LMNANR1I2ALOX5 | |
| SCHEMBL8747826 | 0.70 | AKT1 (0.66) | AKT1PDPK1PHLPP1ILKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452801-A | ANTIINFLAMMATORY AGENTS, ANTICOAGULATNS, ANTIALLERGENS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4360532-A | ANTIINFLAMMATORY AGENTS, ANTICOAGULANTS, ANTIALLERGENS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-11-23 | — | — | US | disclosed |
| US-4321270-A | ANTIINFLAMMATORY AGENT, ANTIAGGLOMERANTS, AND HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-03-23 | — | — | US | disclosed |