Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11080698 | 0.86 | SLC6A4 (0.36) | SLC6A4MAOA | |
| SCHEMBL11078963 | 0.83 | SLC6A4 (0.42) | SLC6A4HIF1AMAOA | |
| SCHEMBL11077824 | 0.72 | SLC6A2 (0.40) | SLC6A4 | |
| SCHEMBL11083445 | 0.72 | SLC6A2 (0.33) | SLC6A4CYP1A2 | |
| SCHEMBL11084940 | 0.72 | SLC6A2 (0.33) | SLC6A4CYP1A2HIF1AHSD17B10 | |
| SCHEMBL11076375 | 0.71 | MAOA (0.40) | SLC6A4CYP1A2HIF1AHSD17B10MAOA | |
| SCHEMBL11079915 | 0.69 | SLC6A4 (0.46) | SLC6A4CYP1A2HIF1AHSD17B10MAOA | |
| SCHEMBL2866808 | 0.68 | SLC6A4 (0.39) | SLC6A4MAOA | |
| SCHEMBL11088866 | 0.68 | PTGS2 (0.38) | SLC6A4HSD17B10MAOA | |
| SCHEMBL11083832 | 0.68 | CYP3A4 (0.33) | SLC6A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |