Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 11/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11283326 | 0.82 | SLC6A2 (0.47) | SLC6A2SLC6A4 | |
| SCHEMBL11081236 | 0.81 | IDO1 (0.41) | SLC6A2SLC6A4CYP3A4CYP2D6SLC6A3 | |
| SCHEMBL11073428 | 0.81 | GABBR2 (0.50) | SLC6A2SLC6A4CYP3A4CYP2D6SLC6A3 | |
| SCHEMBL11083445 | 0.77 | SLC6A2 (0.33) | SLC6A2SLC6A4CYP3A4CYP2D6SLC6A3 | |
| SCHEMBL11084940 | 0.77 | SLC6A2 (0.33) | SLC6A2SLC6A4CYP3A4CYP2D6SLC6A3 | |
| SCHEMBL11080784 | 0.77 | ADRA2A (0.45) | SLC6A2SLC6A4CYP3A4CYP2D6SLC6A3 | |
| SCHEMBL11079597 | 0.72 | TAAR1 (0.53) | SLC6A2SLC6A4CYP3A4CYP2D6SLC6A3 | |
| SCHEMBL11077087 | 0.72 | SLC6A4 (0.33) | SLC6A4 | |
| SCHEMBL11081533 | 0.72 | ADRA2C (0.44) | SLC6A2SLC6A4CYP3A4CYP2D6SLC6A3 | |
| SCHEMBL11078462 | 0.72 | SLC6A2 (0.41) | SLC6A2SLC6A4CYP3A4CYP2D6SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |